One-Time zap: new radiation approach aims to ease spine tumor pain
NCT ID NCT00492817
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a single, precise session of high-dose radiation (stereotactic body radiotherapy) can safely relieve pain and control tumor growth in people with cancer that has spread to the spine. 71 adults with up to two spine tumors participated. Researchers measured pain relief, tumor control, and any nerve damage over 6 months.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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71 people
The number who actually took part.
- Started
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Oct 2005
- Finished
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Nov 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Radiographically documented spine or paraspinal metastasis demonstrated on spine MRI within 4 weeks of registration 2. Maximum of 2 metastatic sites in the spine to be irradiated in single session 3. Informed consent for irradiation of spinal or para-spinal tumor (s) 4. Diagnosis of cancer including but not limited to lung (non-small cell and small cell), breast, prostate, renal cell, melanoma, gastrointestinal, and germ cell tumors, unknown primary tumors 5. Karnofsky performance status of at least 40 (ie not requiring active hospitalization) Exclusion Criteria: 1. Worsening neurological status due to radiographic evidence of spinal cord compression requiring immediate surgical decompression or emergent conventional external radiation therapy. 2. Delay in initiation of radiation treatment would be potentially detrimental to neurological outcome 3. Prior irradiation to current site of interest in the spine 4. Spinal metastasis in the cervical spine are not eligible for treatment 5. Unstable spine requiring surgical stabilization. 6. Sites outside the spine (eg. lung, liver) are not eligible for treatment 7. Patients currently receiving, or who have received chemotherapy within 30 days are not eligible 8. Inability to tolerate lying flat on treatment couch for greater than 30 minutes. 9. Patient with multiple myeloma 10. Patients unable to undergo MRI of the spine 11. Patients with pacemakers
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Other studies related to the condition(s) this trial covers.