M.d. Anderson Cancer Center

This study tested two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the best dose and see if the combination could slow down the cancer. The trial was stopped early after enrolling only 8 participants, so the results a…

This study tested whether the drug repotrectinib, alone or with fulvestrant, could control a specific type of advanced breast cancer called invasive lobular carcinoma. It was for people whose cancer had spread and who had already tried hormone therapy with another drug. The trial…

This study tested a combination of three drugs (magrolimab, azacitidine, and venetoclax) in 110 adults with acute myeloid leukemia (AML) that had come back or not responded to treatment. The goal was to find the best dose and see if the combo could control the disease. The trial …

This study looked at adding two immunotherapy drugs (ipilimumab and nivolumab) to standard radiation for people with advanced HPV-positive throat cancer. The goal was to see if the combination was safe and could shrink tumors more effectively. The trial enrolled 37 participants b…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 people with a rare and aggressive kidney cancer called renal medullary carcinoma. The goal was to see if the combination could shrink tumors or slow cancer growth. The trial was terminated early, so result…

This study looked at whether giving patients their own immune cells (called autologous lymphocyte infusions) after chemotherapy and radiation could help restore their immune system. It involved 26 adults with non-small cell lung cancer or esophageal cancer. The main goal was to s…

This early-stage trial tested whether adding the experimental drug YL-13027 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer that no longer responds to treatment. Only 4 participants were enrolled before the study was st…

This study looked at whether removing liver tumors with surgery, along with chemotherapy, helps people with colorectal cancer that has spread to the liver and lungs live longer compared to chemotherapy alone. The trial planned to include 120 participants but was stopped early aft…

This early-stage study tested the safety of itacitinib, a drug that blocks certain enzymes, in 8 adults who developed bronchiolitis obliterans syndrome (a type of lung scarring) after a donor stem cell transplant. The goal was to see if the drug could stop the lung damage from ge…

This study tested a new approach for people with head and neck cancer that had spread or come back. It combined an experimental drug (NBTXR3) activated by radiation with an immunotherapy drug (pembrolizumab). The goal was to see if this combination could shrink tumors and improve…

This study tested whether combining two drugs, CB-103 and venetoclax, could help control T-cell acute lymphoblastic leukemia (T-ALL) in adolescents and young adults whose cancer had returned or not responded to prior treatment. Only 2 participants were enrolled before the trial w…

This study tested a drug called poziotinib in 93 people with advanced non-small cell lung cancer that has specific changes in the EGFR or HER2 genes. The goal was to see if the drug could shrink tumors. The study was stopped early, but results may help guide future treatments for…

This early-phase study tested a combination of two drugs—ipilimumab (an approved immunotherapy) and MGN1703 (an experimental immune booster)—in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose of MGN17…

This study tested a combination of two drugs, sitravatinib and nivolumab, in 15 adults with advanced clear cell kidney cancer that had worsened after previous treatments. The goal was to see if the combination could shrink tumors or slow the disease. The trial was stopped early, …

This study tested whether adding the targeted drug inotuzumab ozogamicin before and after a stem cell transplant could help control leukemia and lymphoma. It included 15 people aged 12 to 75 with certain blood cancers. The study was stopped early, and researchers focused on safet…

This study looked at using MRI scans to guide radiation therapy for central lung tumors, which are close to important organs like the heart and windpipe. The goal was to see if this approach is safe and works better than standard CT-guided radiation. Only 3 people took part befor…

This early-phase study aimed to see if adding pirtobrutinib to venetoclax could eliminate remaining cancer cells in people with CLL/SLL who still had detectable disease after venetoclax alone. Only 3 adults took part before the trial was stopped. The goal was to measure how many …

This study tested a combination of two drugs, venetoclax and decitabine, in 235 people with certain types of leukemia or related blood cancers that were either newly diagnosed in older adults or had come back after other treatments. The goal was to see how well the drugs worked t…

This early-stage study aimed to test the safety of combining two targeted drugs, adagrasib and olaparib, in people with advanced solid tumors that have a specific KRAS G12C mutation. The trial focused on certain cancers like gynecological, breast, pancreatic, and a type of lung c…

This study tested a drug called ADCT-602 in 37 people with a type of leukemia (B-ALL) that had returned or stopped responding to treatment. The drug uses an antibody to target and attack cancer cells. The main goals were to find the safest dose and see if it could shrink or elimi…

This study tested a combination of two drugs (copanlisib and fulvestrant) in people with advanced endometrial or ovarian cancers that are hormone receptor-positive and have certain gene changes. The goal was to see if the combination was safe and effective. The trial was stopped …

This study tested a combination of targeted drugs (neratinib, pertuzumab, trastuzumab) and chemotherapy for people with advanced or inflammatory breast cancer. The goal was to find the best dose and see if the treatment could eliminate all signs of cancer before surgery. The stud…

This early-phase study tested a drug called plinabulin combined with radiation and immunotherapy in 19 people with advanced cancers (like lung, bladder, or melanoma) that had stopped responding to standard immunotherapy. The goal was to see if the combination was safe and could s…

This early-stage trial tested a combination of two immunotherapy drugs (BMS-986218 and nivolumab) plus precise, high-dose radiation in 13 people with advanced solid tumors that had spread. The goal was to see if this mix could help the immune system attack cancer more effectively…

This study tested a combination of two drugs, futibatinib and pembrolizumab, in people with advanced endometrial cancer that had spread and was not responding to standard treatments. The goal was to see if the combination could shrink tumors or slow the disease. The trial was sto…

This study tested two drugs, omacetaxine and venetoclax, in 24 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that returned or didn't respond to treatment and had a RUNX1 gene change. The goal was to find the best dose and see if the combination could …

This early-stage study tested the drug belantamab mafodotin (Blenrep) as a maintenance therapy to prevent multiple myeloma from returning after a stem cell transplant. It included 6 patients with relapsed or refractory disease. The study was terminated early, so results are limit…

This study tested a combination of two drugs (nab-paclitaxel and alpelisib) given before surgery to people with a specific type of aggressive breast cancer (triple-negative) that had stopped responding to standard chemotherapy. The goal was to see if the combo could shrink tumors…

This study tested whether a combination of two drugs, daratumumab and pomalidomide, could help control multiple myeloma that has returned after a stem cell transplant. The study included 13 adults with relapsed disease. The goal was to see if this maintenance therapy could lead t…

This early-phase trial tested a treatment combining donor natural killer (NK) cells from cord blood with chemotherapy in children and young adults whose solid tumors had returned or stopped responding to standard therapy. The main goals were to check safety and find the best dose…

This study tested whether a combination of levocarnitine (an amino acid) and vitamin B complex could help lower high bilirubin levels caused by two leukemia drugs, PEG-asparaginase and inotuzumab ozogamicin. Only 10 adults with acute lymphoblastic leukemia (ALL) were enrolled. Th…

This study aimed to understand the quality of life for women who were pregnant while receiving breast cancer treatment. Researchers planned to survey 30 survivors using questionnaires. The study was terminated early, so results are limited.

This study aimed to see if an oral form of the drug cladribine works similarly to the standard IV form in people with certain blood cancers like leukemia. Only 3 adults took part before the study was stopped early. The main goal was to check safety and how the drug moves through …

This study tested whether a simple finger device (Vendys II) can measure blood vessel health in children and young adults (ages 6-26) before and after stem cell transplant. The device works by briefly restricting blood flow and then measuring how the vessels respond. The goal was…