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Promising combo for HPV throat cancer hits snag: trial stopped early

NCT ID NCT03799445

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 39 times

Summary

This study looked at adding two immunotherapy drugs (ipilimumab and nivolumab) to standard radiation for people with advanced HPV-positive throat cancer. The goal was to see if the combination was safe and could shrink tumors better than radiation alone. The trial enrolled 37 participants but was stopped early. While the approach aims to control the disease, patients may still need ongoing monitoring or additional treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

The condition(s) this trial relates to.

basaloid squamous cell carcinoma carcinoma of soft palate human papillomavirus-related squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tongue squamous cell carcinoma tonsillar squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.