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Can diet and exercise programs cut cancer risk? new study tests lifestyle changes

NCT ID NCT02194387

Prevention Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants will try text messaging, online tools, or other support to make lasting lifestyle changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

337 people

The number who actually took part.

Started

Sep 2014

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PILOTS I, II AND III: Body mass index (BMI) of 25 or higher OR \< 150 minutes of moderate to vigorous exercise per week OR \< 5 servings of fruit and vegetables per day * PILOTS I, II AND III: Capable of participating in moderate-vigorous unsupervised exercise * PILOTS I, II AND III: Have a cellular telephone and are able and willing to send and receive text messages * PILOTS I, II AND III: Able to read and write English * PILOTS I, II AND III: Have access to internet * PILOT II: BRCA positive OR Lynch syndrome positive individuals * PILOT II (FAMILY MEMBER): Female and male biological and non-biological family members of BRCA-positive individuals OR Lynch syndrome positive individuals * PILOT III: CLL survivors * PILOT III: Has experienced fatigue within the past seven days Exclusion Criteria: * PILOTS I, II AND III: Unable to walk without crutches, walker, cane, or other assistive device * PILOTS I, II AND III: Women who are pregnant (by self-report) * PILOTS I, II AND III: Less than 3 months post-surgery * PILOTS II and III: Currently receiving radiation therapy or cytotoxic chemotherapy

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia BRCA2-related cancer predisposition breast carcinoma breast neoplasm Colorectal Neoplasms, Hereditary Nonpolyposis Fatigue Lynch syndrome ovarian cancer ovarian carcinoma Overweight cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body mass index 25 or greater BRCA1 gene mutation BRCA2 gene mutation Breast carcinoma Cancer survivor Chronic lymphocytic leukemia Fatigue Health status unknown Lynch syndrome Ovarian carcinoma Overweight

Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.