BREAST CARCINOMA

This study compares giving a shorter, higher-dose radiation schedule (hypofractionated radiotherapy) either before or after breast cancer surgery. The goal is to see which timing is safer and works better for different types of non-metastatic breast cancer. About 120 adults with …

This study tests a new drug called GTAEXS617 in 230 adults with advanced solid tumors, including lung, breast, ovarian, pancreatic, and head and neck cancers. The goal is to check the drug's safety, how the body processes it, and whether it can shrink tumors. Participants must ha…

This study tests a new, shorter radiation treatment for women with stage I-III breast cancer who have had a lumpectomy. Instead of weeks of daily radiation, patients receive 5 ultra-high-dose treatments to the whole breast and surgical area at once. The goal is to see if this app…

This study looks at whether giving focused radiation to a few growing cancer spots can let patients with metastatic breast cancer stay on their current drug longer. About 45 adults whose cancer has started to progress after at least a year on first-line treatment will receive rad…

This study tests if a special program can prevent lymphedema (arm swelling) in women having lymph node removal for breast cancer. About 285 women will be followed for at least a year to see if the program reduces swelling and improves quality of life. The goal is to find a better…

This study is testing a new radioactive tracer called [18F]FTT to see if it can make PET/CT scans better at finding solid tumors, including ovarian, breast, and other cancers. About 300 adults with known or suspected tumors will receive the tracer and then have a PET/CT scan. The…

This study is testing whether a special mammogram called CESM (contrast enhanced spectral mammography) can better find the cause of abnormal nipple discharge and detect breast cancer compared to standard mammography. CESM uses an iodine dye injected into a vein to make tissues an…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see if the synthetic method is as good or better at finding cancers while using less rad…

This study is testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well treatment is working. Researchers will enroll 550 adults with suspicious breast lumps or confirmed breast cancer. The goal is to improve diagnosis and track tumo…

This study is testing whether a blood test, called a liquid biopsy, can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue diagnoses in about 490 women. If successful, this could offer a less invasive way to screen…

This study tests a new 3D ultrasound technology to see if it can better tell whether lymph nodes in breast cancer patients are cancerous or not. About 55 adults who already need a lymph node biopsy or have a clip placed will get this extra scan. The goal is to improve accuracy an…

This study tests whether contrast-enhanced ultrasound (CEUS) combined with machine learning can accurately tell if a breast lump is benign or malignant. About 100 women with suspicious breast masses will receive CEUS before their scheduled biopsy. The goal is to see if this appro…

This study tests a new imaging technique called photoacoustic tomography, which uses light and sound to see breast tissue more clearly. It includes women with suspicious or confirmed breast cancer and healthy volunteers. The goal is to find better ways to detect breast cancer, es…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen, adjusted based on each woman's response, can safely reduce breast density—a key risk factor for breast cancer. About 200 women will take part, and the go…

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study tests whether taking low-dose aspirin can lower inflammation and reduce the risk of breast cancer in women who have had a baby within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes. The…

This study tests whether community health advocates can help more people get screened for breast and lung cancer. Researchers will work with 800 eligible adults to see if support from friends and family increases screening rates. The goal is to understand and overcome barriers, e…

This study looks at whether taking low-dose tamoxifen, alone or with high-dose omega-3 fatty acids, can lower breast cancer risk in overweight or obese postmenopausal women who are already at higher risk. About 66 women will take part. The goal is to see if adding omega-3s improv…

This study tests a community program to increase cancer screenings for breast, cervical, and colorectal cancer in low-income women in Central Ohio. The program includes patient education, media campaigns, and training health workers to help women get screened. About 2,067 women w…

This study tests two drugs, acolbifene and low-dose tamoxifen, to see which works better at preventing breast cancer in premenopausal women at high risk. Both drugs block estrogen from fueling breast cell growth. About 80 women will take one of the drugs for six months, and resea…

This study tests whether CBD, THC, or a mix of both can reduce nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 people will take one of these cannabis-based compounds for 12 weeks. The goal is to see if they improve symptom…

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment options with their doctor. About 20 patients currently …

This study tests whether a digital program called Integrative Medicine at Home (IM@Home) can help breast cancer patients feel less tired and more active during radiation treatment. The program includes online cardio and yoga classes. Researchers want to see if 40 patients find it…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests two walking programs for women undergoing chemotherapy for early-stage breast cancer. One program has a fixed weekly walking goal, while the other adjusts the amount of walking based on how each woman responds. The goal is to see which approach better improves ca…

This study tests whether custom 3D-printed external breast prostheses improve comfort, fit, and emotional well-being for breast cancer patients who had a mastectomy without reconstruction. About 50 adults who have had one or both breasts removed will receive a personalized prosth…

This study tests a system called CONCURxP that uses a special medication bag (WiseBag) and text message reminders to help people with metastatic breast cancer take their CDK4/6 inhibitor pills correctly. About 410 patients will either use the bag alone or the bag plus text remind…

This study tests whether easy, at-home breathing exercises can help reduce heart and lung side effects in people undergoing chemotherapy for breast cancer. About 130 adults will do these exercises regularly during their treatment. The goal is to see if this approach is practical …

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goal is to…

This early study tests whether a wearable EEG headband (MUSE-S) can help breast cancer survivors manage anxiety and insomnia. About 40 survivors who have had breast cancer in the past 10 years and currently struggle with anxiety and poor sleep will use the headband for guided med…

This study tests a support program for breast cancer survivors in Western New York. The program includes group sessions and one-on-one mentoring with a long-term survivor. It aims to help women, especially Black women, transition into life after treatment by connecting them with …

This study aims to collect tumor samples and medical information from 2000 people with breast cancer that has come back or spread. Researchers will use these samples to study how the cancer changes and responds to treatments. The goal is to better understand the disease and impro…

This study looks at hair loss in women with breast cancer who are taking hormone therapy (endocrine therapy). While hair loss is a known side effect of chemotherapy, it is less understood with hormone therapy. Researchers will ask 170 women to describe their hair loss symptoms ov…

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and quality in 100 participants before, during, and after chemotherapy or radiation. The goal is to understand why sleep problems happen and how s…

This study looks at DNA from 354 breast cancer patients who took the drug bevacizumab. Some developed high blood pressure, while others did not. Researchers want to find genetic differences that might explain why. The goal is to better predict and manage this side effect in the f…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the right second-line treatment for people with ER-positive, HER2-negative breast cancer that has spread. About 300 participants will be assigned to either hormone therapy or chemotherapy…

This study looks at whether eating white button mushrooms can lower chronic inflammation and improve immune function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammation markers in the blood. The go…

This study is testing a patient navigation program for 126 newly diagnosed breast cancer patients. The program helps patients understand their care options, connect with support services, and overcome barriers to treatment. The goal is to see if this approach can improve health e…

This study follows 2000 adults with newly diagnosed cancers (breast, colorectal, lung, melanoma, or lymphoma) who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps reduce symptoms like pain, nausea, or fatigue, and al…

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will analyze tumor and blood samples from 160 women before surgery to find patterns that might predict survival. No new treatments are tested—the goal is to gather information that could gu…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation causes immune cells to enter the tumor and attack cancer cells. The study involves 36 adults with invasive breast cancer who will receive radiation and…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource that scientists can use in future research on breast cancer, other cancers, and women's hea…

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study aims to find out how many breast cancer patients stop coming for follow-up visits within five years and why. Researchers will contact patients who have fallen out of care to update their health and survival information. The goal is to improve long-term tracking and sup…

This study looks at why some women with benign (non-cancerous) breast disease later develop breast cancer. Researchers will examine tissue samples, mammograms, and genetic information from 4,500 women to find patterns that predict cancer risk. The goal is to improve early detecti…

This study is gathering information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect detailed treatment and toxicity data to better understand and predict short- and long-term side effects. The goal is to improve future patient ca…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also explore what factors help or block women from following through. About 150 women aged 30 to 75 with certain gen…

This study looks at DNA from 575 breast cancer patients to find genetic changes that increase the risk of nerve damage (peripheral neuropathy) from the chemotherapy drug paclitaxel. Researchers compare patients who had severe nerve damage to those who had none, searching for rare…

This study examines DNA from 162 breast cancer patients who received chemotherapy and either did or did not develop congestive heart failure. Researchers are searching for rare genetic changes that may increase the risk of heart damage from cancer treatment. The goal is to better…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking performance in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants complete sho…

This study from Mayo Clinic interviews 20 breast cancer patients who are currently or recently finished radiation therapy. The goal is to understand the physical, emotional, and social effects of radiation dermatitis (skin irritation from radiation). No new treatments are tested;…

This study tests whether a computer-generated character can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. The goal is to see if this approach increases testing rates, especially for minority and rural patients who often lack ac…

This study tests whether an online platform helps cancer patients track medication safety events and concerns while taking oral anticancer drugs at home. About 80 adults with lung, colorectal, breast, or prostate cancer will use the system to log symptoms and issues. Researchers …

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. Researchers want to see if tamoxifen causes these cells to produce too many NETs, which might lead to side effects. About 290 women with ER+ breast cancer who are taki…

This study is looking at a protein called TRPC6 in the blood to see if it can predict which breast cancer patients will develop heart problems from chemotherapy. Researchers will collect blood samples from 200 patients to study genetic changes linked to heart damage. The goal is …

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study tests a new way to find the first lymph node under the arm during breast cancer surgery. Doctors use ultrasound to mark the exact spot, then make a small cut there instead of the usual method. The goal is to see if this leads to a smaller incision, less tissue damage, …

This study looks at whether measuring body fat before and after breast reconstruction surgery can help predict outcomes. About 40 women having a mastectomy followed by immediate reconstruction will take part. The goal is to see if these measurements are easy to collect and if the…

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…