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New blood test could spot 10 cancers before symptoms start

NCT ID NCT06995898

Diagnosis Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 03, 2026 · Updated 10 times

Summary

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how well these tests work and how people and their doctors respond to the results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multi-Cancer Detection (MCD) blood test
What this could lead to
If successful, this could lead to a simple blood test that finds many types of cancer early, when treatment works best.
What could go wrong
This is an early feasibility study, not a final test. The blood tests may not be accurate enough, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages 45-75 years old * Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment * Agree to allow collection of information from their medical records for study-related purposes * Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic * Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion Exclusion Criteria: * Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years * Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible. Persons with a history of prostate cancer that has not been treated are not eligible, regardless of when the diagnosis occurred * Ongoing cancer diagnostic work-up * Ongoing participation in another study of an investigational cancer screening test or technology not currently utilized in routine clinical practice * Currently breastfeeding or pregnant, or planning to become pregnant in the next year * History of solid organ or hematopoietic transplantation at any time, or blood transfusion within the last 30 days

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm cancer carcinoma of esophagus carcinoma of liver and intrahepatic biliary tract colorectal carcinoma colorectal neoplasm Esophageal Neoplasms exocrine pancreatic carcinoma gastric carcinoma gastric neoplasm hepatocellular carcinoma lung carcinoma lung neoplasm ovarian cancer ovarian carcinoma pancreatic adenocarcinoma pancreatic neoplasm prostate cancer prostate carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder carcinoma Breast carcinoma Colorectal carcinoma Esophageal carcinoma Gastric carcinoma Liver carcinoma Lung carcinoma Malignant solid neoplasm Ovarian carcinoma Pancreatic carcinoma Prostate carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    44 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cancer Care and Hematology-Fort Collins

    RECRUITING

    Fort Collins, Colorado, 80528, United States

  • Durham VA Medical Center

    RECRUITING

    Durham, North Carolina, 27705, United States

    Contact Email: •••••@•••••

  • Henry Ford Cancer Institute-Downriver

    RECRUITING

    Brownstown, Michigan, 48183, United States

    Contact Email: •••••@•••••

  • Henry Ford Health Center - Brownstown

    RECRUITING

    Brownstown, Michigan, 48183, United States

  • Henry Ford Health Center - Chesterfield

    RECRUITING

    Chesterfield, Michigan, 48047, United States

  • Henry Ford Hospital

    RECRUITING

    Detroit, Michigan, 48202, United States

    Contact Email: •••••@•••••

  • Henry Ford Macomb Hospital-Clinton Township

    RECRUITING

    Clinton Township, Michigan, 48038, United States

    Contact Email: •••••@•••••

  • Henry Ford Medical Center

    RECRUITING

    Sterling Heights, Michigan, 48310, United States

  • Henry Ford Medical Center - Detroit Northwest

    RECRUITING

    Detroit, Michigan, 48235, United States

  • Henry Ford Medical Center - Livonia

    RECRUITING

    Livonia, Michigan, 48150, United States

  • Henry Ford Medical Center - Plymouth

    RECRUITING

    Plymouth, Michigan, 48170, United States

  • Henry Ford Medical Center - Royal Oak

    RECRUITING

    Royal Oak, Michigan, 48067, United States

  • Henry Ford Medical Center - Troy

    RECRUITING

    Troy, Michigan, 48083, United States

  • Henry Ford Medical Center-Columbus

    RECRUITING

    Novi, Michigan, 48377, United States

    Contact Email: •••••@•••••

  • Henry Ford Medical Center-Cottage

    RECRUITING

    Grosse Pointe Farms, Michigan, 48236, United States

  • Henry Ford Medical Center-Fairlane

    RECRUITING

    Dearborn, Michigan, 48126, United States

    Contact Email: •••••@•••••

  • Henry Ford West Bloomfield Hospital

    RECRUITING

    West Bloomfield, Michigan, 48322, United States

    Contact Email: •••••@•••••

  • Henry Ford Wyandotte Hospital

    RECRUITING

    Wyandotte, Michigan, 48192, United States

  • Inova Fair Oaks Hospital

    RECRUITING

    Fairfax, Virginia, 22033, United States

  • Inova Schar Cancer Institute

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Kaiser Permanente Moanalua Medical Center

    RECRUITING

    Honolulu, Hawaii, 96819, United States

  • Kaiser Permanente-Division of Research

    RECRUITING

    Pleasanton, California, 94588, United States

  • Kaiser Permanente-Franklin

    RECRUITING

    Denver, Colorado, 80205, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Lone Tree

    RECRUITING

    Lone Tree, Colorado, 80124, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Rock Creek

    RECRUITING

    Lafayette, Colorado, 80026, United States

    Contact Email: •••••@•••••

  • Keefe Memorial Hospital

    RECRUITING

    Cheyenne Wells, Colorado, 80810, United States

  • Louis Stokes Cleveland VA Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • Madigan Army Medical Center

    RECRUITING

    Tacoma, Washington, 98431, United States

  • Medical Center of the Rockies

    RECRUITING

    Loveland, Colorado, 80538, United States

  • Minneapolis VA Medical Center

    RECRUITING

    Minneapolis, Minnesota, 55417, United States

  • Naval Medical Center - Portsmouth

    RECRUITING

    Portsmouth, Virginia, 23708-2197, United States

  • Poudre Valley Hospital

    RECRUITING

    Fort Collins, Colorado, 80524, United States

  • Saint Luke's Hospital of Kansas City

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Sentara Martha Jefferson Hospital

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Sentara Norfolk General Hospital

    RECRUITING

    Norfolk, Virginia, 23507, United States

  • UCHealth Greeley Hospital

    RECRUITING

    Greeley, Colorado, 80631, United States

  • UNC Lineberger Comprehensive Cancer Center

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact Email: •••••@•••••

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • VCU Community Memorial Health Center

    RECRUITING

    South Hill, Virginia, 23970, United States

  • VCU Massey Cancer Center at Stony Point

    RECRUITING

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Walter Reed National Military Medical Center

    RECRUITING

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

  • Zablocki Veterans Administration Medical Center

    RECRUITING

    Milwaukee, Wisconsin, 53295, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.