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Can exercise and nutrition prehab help breast cancer patients through chemo?

NCT ID NCT07819981

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers at City of Hope test whether a prehabilitation program is practical for breast cancer patients receiving chemotherapy before surgery. The program includes aerobic exercise, nutrition guidance, and education, all led by a physiatry team. Twenty participants will be asked to follow the plan and attend assessments. The study measures how well people stick to the program and whether it affects fitness and daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a physiatry-led prehabilitation program combining aerobic exercise, nutrition guidance, and education
What this could lead to
If the program proves feasible, it could shape how cancer centers support patients during chemotherapy before surgery, helping them stay stronger and recover more easily.
What could go wrong
This is a small pilot study of 20 people at one center, so it cannot show whether prehabilitation improves outcomes. Many patients may find the exercise and diet targets hard to meet during treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2027

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PATIENT INCLUSION: * Documented informed consent of the participant and/or legally authorized representative * Willingness to comply with a physiatry consultation, start a tailored training program, and follow-up assessments * Age: \>= 18 years * Able to read and write in English * A diagnosis of breast cancer planned for curative intent neoadjuvant systemic treatment (NST) with a goal of breast cancer surgery * Plan to start NST at City of Hope Orange County * HEALTHCARE TEAM INCLUSION: * Willingness to complete the Healthcare Team Feedback Survey * \> 18 years old * Physicians, advanced practice providers, nurses, medical assistants, rehabilitation therapists, social workers, dietitians, mental health professionals, and other clinical staff who interact with study participants in the course of routine care Exclusion Criteria: * PATIENT EXCLUSION: * Current or planned cancer treatment for a second cancer not of breast origin * Clinically significant uncontrolled illness limiting participation with the research intervention and assessments * Cancer with distant metastases * Other active malignancy * Pregnant or breastfeeding * Physician judgment (based on information gathered during consult visit) of medical instability including conditions such as unstable cardiopulmonary status, recent embolism (\< 4 weeks), suspected or known dissecting aneurysm, severe hypertension (resting blood pressure \> 180/110), chronic infectious disease, uncontrolled metabolic disease (e.g. diabetes with ketosis), active seizure, mental/physical impairments limiting safe exercise, or sepsis * Meeting or exceeding exercise guidelines over the last one month, based on the responses from the Godin Leisure-Time Physical Activity and Exercise Intent Questionnaire * Started second cycle before the physiatry consult * Inability to independently follow instructions for study assessments for any reason such as mental incapacitation or significant emotional or psychological disorder that, in the opinion of the investigators, precludes study entry. (These patients may not be able to cooperate with the prehabilitation interventions or with the data collection process.) * Unable to independently answer questionnaires in English or provide informed consent for any reason * HEALTHCARE TEAM EXCLUSION: * Healthcare workers who do not interact with study participants and therefore cannot provide relevant feedback

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

  • City of Hope at Irvine Lennar

    Irvine, California, 92618, United States

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