BREAST CARCINOMA

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 women with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone ther…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tests a combination of three drugs (nivolumab, bicalutamide, and ipilimumab) to control metastatic HER2-negative breast cancer without using chemotherapy. The goal is to see if this approach can shrink tumors or keep them stable for at least 24 weeks. The trial involve…

This study tests whether taking hormone-blocking pills for 6 months before surgery helps remove all cancer cells in one piece for women with early-stage, estrogen-positive breast cancer. Eight postmenopausal women with low-risk tumors are participating. The goal is to see if this…

This study tests whether giving a short course of radiation to the tumor area before surgery is safe and practical for women with early-stage breast cancer. About 98 women over age 50 with small, low-grade tumors will receive radiation, then have surgery. The main goal is to chec…

This early-phase study tests the safety and best dose of the drug veliparib when given with standard chemotherapy (carboplatin and paclitaxel) in adults with advanced solid tumors that also have liver or kidney dysfunction. The goal is to find out how the body processes the drugs…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This study compares two different chemotherapy combinations given before surgery for a fast-growing, hard-to-treat type of breast cancer called triple-negative inflammatory breast cancer. Researchers want to see if adding a targeted drug called panitumumab to standard chemotherap…

This study tests a new radioactive tracer called [18F]FluorThanatrace (FTT) used with PET/CT scans to improve breast cancer imaging. About 36 adults with known breast cancer will receive the tracer before standard surgery or biopsy. The goal is to see if FTT can help detect cance…

This study looks at whether a special type of mammogram (contrast-enhanced mammography) can more accurately predict breast cancer in women with large, suspicious calcium spots found on standard mammograms. About 59 women will be enrolled to compare the new imaging with standard m…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively highlight cancers in the breast, colon, lung, pancreas, and related metastases. About 27 adults with these cancers will receive the tracer and undergo PET scans. The g…

This study tests a special mammogram that uses a dye injected into the arm to make breast tissue and blood vessels show up more clearly. The goal is to see if this method can find breast cancer better than standard mammograms in women with suspicious breast changes. About 100 wom…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which program works best to improve waist size and overall health, whi…

This study tests whether a personalized diet and exercise program can reduce breast cancer risk in normal-weight postmenopausal women who have excess body fat. About 40 women will take part in a 16-week program with a personal trainer and health coaching. The goal is to lower inf…

This study tests whether a patient navigation program helps women at high risk for breast cancer make informed decisions about risk management, like screenings or preventive steps. About 75 women with a family history of breast cancer but no personal diagnosis will receive guidan…

This study tests a surgical procedure called vascularized lymph node transfer to lower the risk of lymphedema (arm swelling) in breast cancer patients having breast reconstruction. About 30 women who have already had mastectomy, lymph node removal, and radiation will receive this…

This study looks at adults with certain cancers (like lung, breast, kidney, or melanoma) that have spread to the brain. All participants are also receiving immunotherapy. The goal is to see if giving a lower dose of radiation over a few days causes fewer side effects than the sta…

This study tests a mobile program to help women with breast cancer eat healthier, exercise more, and manage stress. About 30 women who have had chemotherapy and surgery will receive coaching on diet, physical activity, mindfulness, and sleep. The goal is to see if the program is …

This study looks at whether adding a simple picture guide to standard counseling can help lower anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 women will take part, and their stress levels will be tracked using qu…

This research study aims to collect tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early in certa…

This study looks at why some women may want to get their screening mammogram results during the same visit instead of waiting. Researchers plan to survey female patients aged 30 and older at MD Anderson breast imaging centers. The goal is to understand patient preferences and imp…

This study looks at whether a simple online questionnaire called MammoScreen can help identify women who need extra breast cancer screening. About 1,100 women aged 40 to 74 will use the tool through their patient portal. The goal is to see if it increases appropriate screening an…

This study was designed to check if getting an IV in the arm of breast cancer patients who had lymph node surgery increases their risk of lymphedema (arm swelling). Researchers planned to use a safe dye called indocyanine green and a special camera to see how the lymph system wor…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study explores whether a computer algorithm called ENLIGHT can help choose approved drugs for people with advanced breast cancer that has stopped responding to treatment. About 175 adults with triple-negative or hormone-resistant breast cancer will have their tumor tested. B…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study examines skin and soft tissue removed during breast implant reconstruction surgery in women who have had a mastectomy. Researchers want to see if the physical properties of the skin can help predict complications like implant loss. The goal is to better understand risk…

This study follows 140 breast cancer patients who were part of the original BEAUTY study. Researchers will collect blood and tissue samples over time to learn why some breast cancers respond well to standard chemotherapy while others do not. The goal is to find clues that could l…

This study tests whether a genetic counseling program delivered through a hospital's online patient portal works as well as traditional in-person counseling for women at elevated risk for breast cancer. About 874 women will take part, and researchers will compare how well each gr…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study tests a computer app designed to help breast cancer patients make informed decisions about breast reconstruction surgery. The app shows personalized images of possible outcomes based on each patient's treatment options and preferences. Researchers want to see if using …