BREAST CARCINOMA

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if spreading radiation over several days causes fewer side effects than giving it all at once. The trial will enroll 244 adults…

This study is testing a much shorter radiation schedule for women with early-stage breast cancer who have had a lumpectomy. Instead of radiation treatments spread over 3-6 weeks, this approach delivers all needed radiation in just 5 daily sessions. The main goal is to see if this…

This study is testing a new drug called GTAEXS617 in people with advanced solid tumors that have stopped responding to standard treatments. Researchers want to find the safest dose and see if the drug can shrink tumors in cancers like lung, pancreatic, ovarian, and breast cancer.…

This study is testing whether a smart pillbox, combined with text message reminders, can help people with advanced breast cancer remember to take their oral medication correctly. The goal is to see if this technology helps patients stick to their complex treatment schedule better…

This study is testing whether a patient navigation program can help reduce disparities in breast cancer care. The program helps newly diagnosed women understand their treatment options, connect with support services, and overcome barriers to getting care. Researchers want to see …

This study is testing if changing the order of breast cancer treatments improves how women feel about their bodies after surgery. It compares giving radiation therapy before breast removal and reconstruction (the new approach) to the standard method of radiation after surgery. Th…

This trial aims to help doctors choose the most effective second treatment for people with advanced breast cancer that has stopped responding to initial hormone therapy. It uses special scans and blood tests to guide whether patients should receive more hormone-based treatments o…

This study is testing whether giving a shorter, more intense course of radiation therapy *before* breast cancer surgery is as safe and effective as giving it *after* surgery. It aims to see if the pre-surgery timing can reduce side effects and treatment time for 120 patients with…

This study is testing whether a computer algorithm called ENLIGHT can find better treatment options for people with aggressive, metastatic breast cancer that has stopped responding to standard therapies. Researchers will analyze a tumor sample from each participant using the algo…

This study is for people with metastatic breast cancer whose current medication is working well but who have a few new spots of cancer growth. Researchers want to see if using very precise, high-dose radiation on just those few spots can control them, allowing patients to safely …

This study is testing a new imaging method called photoacoustic tomography. It combines light and sound waves to create pictures of breast tissue, with the goal of getting clearer images, especially for people with dense breasts. The study is enrolling 400 women, including those …

This Mayo Clinic study is testing whether a new type of breast ultrasound can better detect breast cancer and monitor how well treatment is working. The research involves 550 participants who will undergo special ultrasound scans to see if this method can identify cancerous tissu…

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing if a special type of mammogram called CESM is better than standard scans at finding the cause of unusual nipple discharge. CESM uses a safe dye injected into the vein to make breast tissue clearer on the images. The goal is to see if this method can more acc…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This early study is testing a new 3D ultrasound imaging technology to see if it can better evaluate lymph nodes in people with breast cancer. Researchers want to know if this 3D method is more accurate than standard 2D ultrasound at telling if a lymph node is cancerous or benign.…

This study is testing whether combining a special contrast-enhanced ultrasound with artificial intelligence (AI) can better determine if suspicious breast masses are cancerous or benign. Researchers will scan 100 women who have been recommended for a biopsy to see if this approac…

This study is comparing two ways of creating mammogram images to see which helps doctors better spot breast cancer. Researchers will look at the medical records and past scans of 750 women to analyze the performance of a newer image type called 'synthetic mammography' against the…

This study is testing whether using an ultrasound machine to guide where surgeons make an incision during breast cancer surgery helps them find the first lymph node more easily. Researchers will compare this ultrasound-guided method to the standard technique in 40 patients. They …

This study is testing whether a new type of blood test, called a liquid biopsy, can accurately detect breast cancer. Researchers will compare the blood test results to standard methods like mammograms and biopsies in 490 women. The goal is to see if this easier test could one day…

This study is testing two medications, acolbifene and a low dose of tamoxifen, to see if they can help prevent breast cancer in premenopausal women who are at high risk for developing it. About 80 participants will take one of the pills daily for six months. Researchers will chec…

This study is testing a personalized approach to using the drug tamoxifen to prevent breast cancer in premenopausal women at higher-than-average risk. Researchers want to see if starting with a low dose and increasing it only for women who don't show a good initial response on th…

This study is testing whether people who get screened for breast or lung cancer, or their supportive friends and family, can encourage others to get screened too. Researchers want to see if this 'sphere of influence' approach can increase screening rates, especially for lung canc…

This study is testing whether a comprehensive prevention program can help drain fluid from the arm and stop lymphedema (chronic arm swelling) from developing. It involves 285 women with breast cancer who are having surgery to remove lymph nodes under their arm. The main goal is t…

This study is testing whether a low dose of the drug tamoxifen, taken with or without high-dose omega-3 fish oil supplements, can help prevent breast cancer in women at high risk. It is for overweight or obese postmenopausal women who have specific risk factors, like a family his…

This study is testing whether taking a daily low-dose aspirin can reduce inflammation in breast tissue, which might help prevent breast cancer in women who have recently had a baby. It involves 100 women under age 45 who have given birth within the last 10 years and need a breast…

This study is testing a community program designed to help more low-income and uninsured women get screened for breast, cervical, and colorectal cancer. The program works with clinics, healthcare providers, patients, and entire communities through education, reminders, and outrea…

This study is testing whether a patient navigation program can help women at high risk for breast cancer access and use recommended prevention strategies. The program provides information and monthly phone support to help participants understand their risk and options like geneti…

This study is testing whether two compounds from the cannabis plant, CBD and a THC:CBD mix, can reduce chronic nerve pain caused by chemotherapy. The trial will involve 120 breast and colon cancer survivors who have finished treatment but still experience pain, tingling, or numbn…

This study is testing whether virtual reality (VR) relaxation programs can help reduce pain in people with cancer. Researchers will use a special, non-invasive brain scanner to measure pain levels objectively. The goal is to understand how VR distracts the brain from pain and whe…

This study is testing whether a custom 3D-printed external breast prosthesis can improve comfort, fit, and emotional well-being for people who have had a mastectomy and did not have surgical reconstruction. Researchers will create personalized prostheses using 3D scans and compar…

This study is testing two different walking exercise programs for women with breast cancer who are receiving chemotherapy. The goal is to see which approach is better at reducing the severe fatigue that often comes with cancer treatment. One program uses a fixed weekly walking sc…

This study is testing an online platform designed to help cancer patients track their experiences and concerns about their medications while at home. The goal is to see if this tool makes it easier for patients to monitor side effects and communicate problems to their doctors, po…

This study is testing a free support program designed to help breast cancer survivors in Western New York transition to life after their main cancer treatments are finished. The program combines group support sessions with one-on-one mentoring from a long-term survivor. Researche…

This study is testing whether a 12-week program of breathing exercises done at home can help reduce side effects for people undergoing chemotherapy for breast cancer. The exercises aim to strengthen breathing muscles and may help lessen heart and lung strain, fatigue, and stress …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study aims to understand if using cannabis or related products helps people manage symptoms like pain and nausea during cancer treatment. It will follow 2,000 adults newly diagnosed with certain cancers who are starting chemotherapy or immunotherapy. Researchers will track p…

This study is testing whether a virtual exercise and wellness program can help reduce fatigue and improve symptoms for breast cancer patients undergoing radiation treatment. Participants will use activity trackers and try online classes like yoga, tai chi, and cardio. The goal is…

This small, early study is testing whether a wearable headband that guides meditation can help breast cancer survivors manage anxiety and insomnia. Forty participants who report these symptoms will use the headband at night and for short daily meditations over 8 weeks. The main g…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study aims to understand why some breast cancer patients develop nerve damage (peripheral neuropathy) from the chemotherapy drug paclitaxel, while others do not. Researchers will analyze the DNA of about 575 patients who previously received this treatment to look for genetic…

This study aims to understand why some breast cancer patients develop heart problems after certain chemotherapy drugs. Researchers will collect blood samples from 200 patients to look for a specific marker (TRPC6) that might predict this risk. The goal is to learn how to identify…

This study aims to collect information from 10,000 women over five years to help researchers better understand breast cancer. Participants will provide blood samples, answer health questionnaires, and have their routine mammogram images collected. The goal is to create a large da…

This study collects blood and tissue samples from patients with recurrent or metastatic breast cancer to create a research resource. Researchers will use these samples to better understand how breast cancer spreads and responds to treatments. The study involves 2,000 participants…

This study is testing a new radioactive tracer used in PET/CT scans to see if it can better find and track cancer cells in people with solid tumors, including ovarian, breast, and other cancers. Researchers will inject the tracer and perform scans to see how well it highlights tu…

This study aims to understand why some breast cancer patients develop heart problems after certain treatments while others do not. Researchers will analyze stored DNA samples from 162 patients who previously received chemotherapy. By comparing the genes of patients who developed …

This study aims to understand why some breast cancer patients develop severe high blood pressure as a side effect of the drug bevacizumab. Researchers will analyze the DNA of 354 patients who either did or did not develop this side effect during a previous clinical trial. The goa…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This study aims to test a simple method for understanding the daily lives of breast cancer survivors. Researchers want to see if a 14-day mobile phone diary is a practical way to track daily stress and thinking patterns. They will recruit 30 diverse survivors who are at least fiv…

This study is developing and testing a decision-making tool to help women with early-stage breast cancer choose their treatment options. Researchers will compare how the tool affects communication with doctors and decision-making satisfaction. The study involves 180 participants,…

This study aims to better understand the skin reactions that breast cancer patients experience during radiation therapy. Researchers will interview 20 patients about how these skin changes affect their physical comfort, emotions, and daily activities. The goal is to gather firsth…

This study is looking at whether taking a daily white button mushroom powder supplement for three months can change certain markers of inflammation and immune cells in the body. It involves 26 obese, postmenopausal women who are at high risk for developing breast cancer. The goal…

This study aims to see if adding a genetic risk score to standard breast cancer risk assessments helps African American and Hispanic women make more informed decisions about screening and prevention. Researchers will follow 50 women with elevated breast cancer risk for 10 years t…

This study aims to better understand why some women with benign breast conditions develop cancer later. Researchers will analyze tissue samples, mammograms, and genetic information from 4,500 women who had benign breast biopsies. The goal is to identify patterns that predict futu…

This study is testing whether a multilingual AI chatbot named PERLA can help more cancer patients get important genetic testing. It compares patients who learn about testing from the chatbot to those who learn from a human genetics counselor. The goal is to see if this technology…

This study aims to better understand hair loss caused by hormone therapy drugs used to treat breast cancer. Researchers will follow 170 women with breast cancer who are taking different types of hormone therapy. By having patients regularly report their hair loss symptoms, the st…

This study aims to understand how long-term tamoxifen treatment affects certain immune cells called neutrophils in breast cancer patients. Researchers will collect blood samples from 290 women with estrogen-positive breast cancer who have been taking tamoxifen for different lengt…

This study aims to understand how often women at a moderately increased risk for breast cancer follow through with recommended screening. Researchers will compare two groups: women with specific gene changes and women with a high calculated lifetime risk. By reviewing medical rec…

This study aims to understand how breast cancer treatment affects sleep patterns and quality. Researchers will follow 100 patients with early-stage breast cancer, having them wear sleep trackers and complete surveys from treatment through recovery. The goal is to identify factors…

This study aims to understand why many breast cancer survivors stop attending their long-term follow-up appointments. Researchers will track 1500 women treated in 2017-2018 to see how many are lost to follow-up after five years. They will then try to contact those who have stoppe…

This study aims to understand how cancer-related genetic mutations differ among various ethnic populations. Researchers will collect blood or saliva samples from 1,800 cancer patients from diverse backgrounds to identify genetic patterns. The findings could help create more perso…