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New hope for tough colon cancer: targeted drug combo trial launches

NCT ID NCT05722327

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 21 times

Summary

This early-phase trial tests a new drug, adagrasib, combined with two existing cancer drugs (cetuximab and irinotecan) in 24 people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effects. This approach aims to control the disease, not cure it, and participants will likely need ongoing treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.