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New painkiller could ease chest tube placement

NCT ID NCT05044468

Symptom relief Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two numbing medicines, EXPAREL and lidocaine, in 80 people with lung cancer who need a procedure called pleuroscopy. The goal is to see which one provides better pain relief after the procedure. Participants will receive one of the two drugs and report their chest pain levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Liposomal bupivacaine (EXPAREL) and lidocaine
What this could lead to
If it works, this could provide better pain control for patients undergoing a lung procedure, making recovery more comfortable.
What could go wrong
This is a small, early-phase trial with only 80 participants, so results may not apply to everyone. There is also a risk of allergic reactions or the drug not working as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2021

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Referral to pulmonary services for pleuroscopy with biopsies and IPC placement/chest tube placement 2. Age \> 18 Exclusion criteria: 1. Inability to provide informed consent 2. Study subject has any disease or condition that interferes with safe completion of the study including: a. Allergic reaction to EXPAREL 3. Need for pleurodesis 4. Allergies to lidocaine or other local anesthetics. 5. Pregnancy 6. Advanced liver disease where the clinician deems the procedure unsafe

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Conditions

The condition(s) this trial relates to.

pleural cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malignant pleural neoplasm

Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.