Can a shot in the mouth stop precancer?
NCT ID NCT05327270
First seen Jan 07, 2026 · Last updated Jun 18, 2026 · Updated 25 times
Summary
This early-phase study tests whether injecting the immunotherapy drug nivolumab directly into high-risk oral precancerous lesions is safe and can shrink or control them. About 18 adults with visible, untreated mouth lesions will receive the injections. The goal is to see if this approach can prevent progression to head and neck cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.