Could breast cancer patients avoid surgery? new trial tests less treatment
NCT ID NCT02945579
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 34 times
Summary
This study is for people with certain types of breast cancer (HER2-positive or triple-negative) who have a complete response to initial drug therapy. It tests whether they can safely skip surgery and only receive radiation, or skip radiation if surgery shows no cancer left. For another group (ER-positive/HER2-negative), it tests skipping surgery after hormone therapy and radiation. The goal is to see if less treatment can still keep cancer from coming back.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baptist MD Anderson Cancer Center
RECRUITINGJacksonville, Florida, 32207, United States
Contact
Contact Email: •••••@•••••
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Carolinas Medical Center/Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cooper Hospital Univ Med Ctr, MD Anderson at Cooper Voorhees
RECRUITINGVoorhees Township, New Jersey, 08103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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MD Anderson Cancer Center - Banner
COMPLETEDGilbert, Arizona, 85234, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Queen's Medical Center
COMPLETEDHonolulu, Hawaii, 96813, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (external beam radiotherapy or partial breast irradiation)
What this could lead to
If successful, this could allow some breast cancer patients to avoid surgery or additional radiation, reducing side effects and recovery time while maintaining cancer control.
What could go wrong
This is an early-phase trial with only 120 participants, so results may not apply to all patients. There is a risk that skipping standard treatments could lead to cancer recurrence.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.