INVASIVE BREAST CARCINOMA

This study is testing whether certain breast cancer patients who respond extremely well to initial drug therapy can safely skip surgery or radiation. For HER2-positive and triple-negative breast cancers, if a biopsy shows no cancer left after drug treatment, patients receive only…

This study looks at whether metformin, a common diabetes medicine, can help prevent or reverse insulin resistance (a step toward diabetes) in women who finished chemotherapy for early-stage breast cancer. About 200 women will either get metformin plus standard diet and exercise a…

This early-stage trial tests the safety and best dose of combining two drugs—pidnarulex and trastuzumab deruxtecan—in people with advanced breast cancer or other solid tumors that have a protein called HER2. The study includes up to 36 adults whose cancer has spread, cannot be re…

This study tests whether adding a personalized vaccine (neoantigen vaccine) to a standard chemo-immunotherapy combination helps control metastatic triple-negative breast cancer better than the combination alone. About 70 adults with this aggressive, advanced breast cancer will re…

This study looks at whether cutting calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the diet hel…

This early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…

This study tests a new imaging system that uses light to monitor how well breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone, which could help some patients avoid additional treatments. Th…

This study compares a new single-port robotic surgery to standard open surgery for early-stage breast cancer. The robotic approach works through the armpit to hide scars and may lead to faster recovery. About 100 women aged 18 to 65 who want no chest scar and meet other criteria …

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of mu…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation causes immune cells to enter the tumor and attack cancer cells. The study involves 36 adults with invasive breast cancer who will receive radiation and…

This study creates a registry of medical information and biological samples (blood, tissue, stool) from people with inflammatory or invasive breast cancer. The goal is to help researchers better understand and treat inflammatory breast cancer in the future. Participants do not re…

This study looks at how the COVID-19 pandemic impacted the financial burden on breast cancer patients having surgery. Researchers will survey 600 patients about out-of-pocket costs, lost wages, and economic strain. The goal is to understand the financial challenges these patients…

This study is testing a decision-making tool for women newly diagnosed with early-stage breast cancer. The tool helps them weigh the option of removing the healthy breast as a preventive measure. Researchers want to see if the tool is clear, balanced, and reduces confusion when m…

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer who are about to start chemotherapy. Researchers will measure these molecules before and after treatment to see if changes can predict how well the cancer responds. The goal is t…

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository for future research into how individual factors affect long-term cancer outcomes. Participants wil…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Normally, these patients need more extensive surgery because their cancer is advanced. The study will enroll 75…