Can an antibiotic shorten chest tube time for cancer patients with lung fluid?
NCT ID NCT03465774
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 30 times
Summary
This study looks at two ways to treat malignant pleural effusion, a buildup of fluid in the lungs caused by cancer. One uses a small tube (indwelling pleural catheter) to drain fluid; the other adds the antibiotic doxycycline to help seal the lung. Researchers want to see if adding doxycycline lets patients have the tube removed sooner. About 208 adults with cancer-related fluid buildup will take part.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PLEURAL NEOPLASM are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline
What this could lead to
If adding doxycycline works, patients may need the chest tube for a shorter time, reducing discomfort and infection risk.
What could go wrong
This is an early observational study, not a large randomized trial. Doxycycline may not speed up recovery and could cause side effects like pain or infection.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.