Mouth disorder

This completed Phase 3 study tested whether a battery toothbrush paired with a stannous fluoride toothpaste is more effective at reducing plaque and gingivitis than a regular fluoride toothpaste with a manual toothbrush. 130 adults with mild gum disease brushed twice daily for 12…

Researchers are testing whether combining cetuximab, a drug that blocks tumor growth, with stereotactic body radiation therapy can help patients whose head and neck cancer has returned after earlier radiation and cannot be removed by surgery. The trial enrolls about 45 people wit…

Researchers compare two common mouthwashes to see which reduces dental plaque more effectively in young patients with gum inflammation. Sixty patients aged 15 to 25 use either a chlorhexidine rinse or an essential oil rinse twice daily for three months. The team measures plaque o…

Researchers test whether antimicrobial photodynamic therapy, a light-activated treatment, can reduce bacteria in infected baby front teeth better than standard root canal cleaning. The trial enrolls children aged 2 to 5 with a single-rooted front baby tooth that has died from dee…

This study will test a gentler way to fix cavities in children's permanent molars using the Hall Technique, which places a stainless steel crown without drilling or numbing shots. Ten children will get either the Hall Technique or the standard method (with drilling and anesthesia…

This trial investigates whether using a socket sealing abutment, with or without bone graft material, helps preserve bone and soft tissue after immediate molar implant placement. Adults aged 18-45 with non-restorable molars will receive the implant right after extraction, and the…

Researchers at Al-Azhar University are testing whether a diode laser combined with a green dye and a remineralizing agent can reduce the surface area of white spot lesions on teeth. The trial enrolls 90 people aged 13 to 40 who have good oral hygiene and no other health condition…

This Phase 3 trial tests dazodalibep, a drug given by IV, in 651 people with moderate-to-severe Sjögren's syndrome. The goal is to see if it reduces disease activity and improves symptoms like dryness and fatigue. Participants receive either the drug or a placebo, and researchers…

Braces make it harder to clean teeth, which can lead to swollen, bleeding gums. Researchers are comparing two common oral care routines in 60 adults aged 18 to 35 who wear fixed braces. One group brushes with triclosan toothpaste, another brushes and rinses with chlorhexidine mou…

Researchers compare two powered toothbrushes, one with a side-to-side motion and one with an oscillating-rotating motion, to see which removes more dental plaque and reduces gingivitis. About 295 healthy non-smoking adults, aged 18 to 59, brush twice daily with their assigned too…

This study tests whether watching a video about brushing and flossing is as effective as a hands-on demonstration with a 3D model for people with gingivitis (early gum disease). Eighty adults with gingivitis will receive either a video link or a live demo, and their gum health wi…

This study tests three different fluoride treatments—silver diamine fluoride gel, a special fluoride varnish, and a standard fluoride gel—to see which one best stops early childhood cavities. Ninety healthy children with at least one active cavity will receive one of the treatmen…

Researchers are testing whether a 5% nanochitosan paste can treat oral candidosis, a fungal infection common under dentures. The trial compares this experimental paste with a standard nystatin ointment in 30 adults who wear full dentures and have type 2 denture stomatitis. Partic…

This trial tests whether patient-specific PEEK implants, custom-made plastic pieces, can rebuild the bone under the eye after surgery to remove part of the upper jaw due to tumors. The goal is to keep the eye in its natural position and avoid a sunken appearance or vision problem…

This trial tests whether an injectable, tooth-colored filling material works as well as a conventional one for repairing cavities in back teeth. Researchers will place both types of fillings in the mouths of 38 healthy young adults, each person getting both materials in different…

This trial tests whether 3D-printed dentures work as well as conventionally made ones for people who have lost all their teeth. Each participant will wear both types of dentures for a set period, and researchers will measure how accurately each fits, how much force they can bite …

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This study tested whether a custom digital surgical guide helps dentists perform crown lengthening more accurately than the usual method. Twenty-four adults with gummy smiles due to a condition called altered passive eruption took part. The digital guide uses 3D scans and imaging…

This trial compares two attachment systems, OT-Equator and Ball and Socket, used to hold a lower denture in place with a single dental implant. Researchers will measure how much force is needed to pull the denture off, along with gum health and bone levels, over 12 months. The go…

This trial tests whether a spermidine-based gel can improve the treatment of peri-implant mucositis, a condition where the gums around a dental implant become inflamed. Researchers will compare standard non-surgical cleaning alone against cleaning plus the gel in 20 adults with a…

This trial tests whether placing a graft made from the patient's own tooth and blood components into an extraction socket improves bone healing compared with letting the socket heal on its own. Adults with non-restorable teeth will receive either the graft or no graft, and resear…

This trial tests whether a structured early mobilization program helps people recover faster after abdominal surgery. Half of the 130 participants will follow a gradual schedule of getting out of bed within the first 24 hours after surgery, while the other half receives routine c…

This trial tests whether aloe vera gel can relieve the pain and sores of oral lichen planus as effectively as a standard corticosteroid gel. Adults aged 25 to 60 with confirmed painful oral lichen planus will apply either aloe vera or the steroid four times daily for two months. …

This trial tests whether a deep dental cleaning, called non-surgical periodontal therapy, can reduce inflammation in people who have received a heart transplant. Heart transplant recipients often have low-level inflammation that may harm the new heart, and gum disease can be a hi…

This study tests a honey-based paste against a standard steroid ointment for treating painful mouth sores caused by oral lichen planus. Fifty-six adults with erosive or atrophic lichen planus will use the paste daily for four months. Researchers will track symptom improvement, pa…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This trial tests whether adding insulin to autologous serum eye drops (made from a patient's own blood) improves symptoms and signs of moderate to severe dry eye in people with autoimmune conditions like Sjögren's syndrome. Researchers will compare standard serum drops against se…

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This trial tests whether applying a gel made from a patient's own blood—called injectable platelet-rich fibrin (i-PRF)—to the surgical site after gum removal surgery (gingivectomy) improves healing. In a split-mouth design, one side of the mouth receives i-PRF, while the other si…

This trial is testing whether temporary dental crowns made with modern CAD/CAM milling machines stay more color-stable and cause less tooth sensitivity than those made the traditional way. Adults needing fixed dental work will receive one of three temporary crown materials: two m…

This trial tests a zirconia wing bridge, a false tooth with two wings bonded to the back of neighboring teeth, as a way to replace a single missing front tooth. About 8 people with one missing front tooth will receive the bridge and be checked every 6 months to see if it stays fi…

This trial tests whether adding a medicated gel to standard deep cleaning helps reduce gum inflammation more than cleaning alone. About 120 adults with plaque-induced gingivitis will use either a chlorhexidine gel, a chlorhexidine-plus-metronidazole gel, or a placebo gel twice da…

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This trial explores whether a bioceramic sealer, used alone, can effectively fill root canals in baby molars when the permanent successor is missing. Thirty healthy children with deep decay in a lower second baby molar will receive the treatment and be followed for up to two year…

This trial tests whether two newer root canal cleaning devices—GentleWave and Waterlase—can improve healing compared to the standard ultrasonic method. About 120 people needing a root canal will be randomly assigned to one of the three techniques. The study tracks how well the in…

This trial tests four different materials used in pulpotomy, a procedure that removes infected pulp from a decayed baby tooth to save it. About 140 children aged 4 to 9 with deep cavities in their primary molars will receive one of the four materials. Researchers will check the t…

This study tested a new type of dental implant called T3 to see if it helps preserve the jawbone better than a standard implant. Forty adults who needed dental implants took part. Researchers checked how well the implant stayed in place and how much bone was kept over time.

This clinical trial is testing whether dental implants can be placed at the same time as a sinus lift procedure, or if it is better to wait four months for the graft to heal first. The study involves adults who need sinus augmentation to support dental implants in an upper jaw wi…

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This study is testing whether applying a silver diamine fluoride gel followed by a fluoride varnish can stop cavities in children's baby teeth. Researchers will follow 237 children for a year to see how many cavities become inactive and whether parents are satisfied with the trea…

This trial tests whether herbal mouthwashes containing tea tree oil, thyme hydrosol, or essential oils can reduce the plaque and gum inflammation seen in gingivitis. About 52 adults with gingivitis will use one of these mouthwashes or a placebo twice daily for three months, along…

This trial tests two gentler ways to treat cavities in children's baby molars: the Hall technique, which fits a stainless steel crown without removing decay, and atraumatic restorative treatment (ART), which uses hand tools and adhesive fillings. It compares these to the conventi…

This trial asks whether a newer filling material called zirconomer holds up better than a standard glass ionomer cement when repairing cavities in children's baby molars. About 30 children aged 5 to 7 with a cavity in a back baby tooth will receive one of the two fillings. Resear…

This trial tests three types of tooth-colored fillings in children's baby molars to see which performs best. It compares a preheated bulk-fill composite with two indirect composite systems, looking at how well they hold up, how they look, and whether they cause any problems. The …

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This trial investigates whether a topical clobetasol gel can change the levels of microRNAs in the gum fluid of people with oral lichen planus, a chronic inflammatory condition. Participants will apply either the active gel or a placebo to their lesions, and researchers will comp…

This study compares two types of tooth-colored fillings—alkasite and glass ionomer—for cavities in baby molars. Children aged 5 to 7 with decayed molars will receive one of the two materials, and the fillings will be checked over time for signs of new decay, color match, and how …

This trial tests two different mouthwashes—benzydamine hydrochloride and super saturated calcium phosphate—to see which better prevents and manages oral mucositis, a painful inflammation of the mouth lining, in head and neck cancer patients receiving radiation therapy. Participan…

This trial tests whether adding a procedure to shrink the inferior turbinates—small structures inside the nose—during adenoidectomy gives children aged 9 to 18 better relief from nasal blockage and sleep-disordered breathing than adenoidectomy alone. Participants have both adenoi…

This trial tests whether a three-tone plaque-disclosing gel, which stains old and new plaque in different colors, can help people with gingivitis clean their teeth more effectively than standard brushing instructions alone. Sixty-four adults with gingivitis will be randomly assig…

This study tested whether giving lower doses of radiation after surgery for head and neck cancer could reduce long-term side effects like dry mouth and trouble swallowing, while still keeping the cancer from coming back. About 200 patients with certain stages of oral, throat, or …

This trial tests whether applying a liquid growth factor solution (LPCGF) to the tooth root during standard gum graft surgery can improve gum thickness and coverage. Twenty adults with receding gums will receive either the standard treatment or the standard treatment plus LPCGF. …

This trial tests whether photodynamic therapy (PDT) using methylene blue can control early-stage pericoronitis, a painful gum infection around partially erupted wisdom teeth. Thirty-four healthy young adults with early pericoronitis will receive either standard irrigation or PDT,…

This trial tests whether a calcium silicate cement outperforms the standard calcium hydroxide material when used to treat deep cavities close to the tooth's nerve. Adults aged 18 to 45 with at least one deep cavity will receive one of the two materials after partial decay removal…

This study compares two types of dental implants in people who need a short-span fixed bridge (fewer than four implants). One implant has a lateralized design intended to preserve the crestal bone around it, while the other is a standard version. The goal is to see whether the la…

This trial tests whether adding an interdental brush, water flosser, or rubber toothpick to twice-daily toothbrushing reduces plaque and gum bleeding more than brushing alone. Twenty-nine dental students with gingivitis will use each method in different sections of their mouth fo…

This study tests whether a combination of injectable platelet-rich fibrin (I-PRF) and a collagen membrane can improve coverage of receding gums. The trial includes adults with Miller Class II gum recession, a condition where the gum margin has moved away from the tooth. Participa…

This trial tests whether short dental implants can work as well as standard implants placed after sinus surgery for people with limited bone height in the upper back jaw. Participants have partial tooth loss and a shallow sinus floor that would normally require a sinus lift proce…

This trial compares two types of dental implant surfaces—Nanotite and Osseotite—to see which one integrates more successfully when placed by graduate students learning implant surgery. The study includes adults who already need dental implants for missing teeth. The goal is to fi…

This study looks at whether a specific dental implant can hold a temporary bridge right after being placed, so patients don't have to wait months for a permanent restoration. Researchers will follow 75 adults with missing back teeth who need a short bridge. The main question is w…

This trial tests whether a dental implant with a special lateralized design (Osseotite Certain Prevail) preserves more bone around the implant than a standard version. About 100 adults who need a short fixed bridge to replace missing teeth will receive one of the two implant type…

This pilot study tests whether micro-needling, combined with a gum-lifting procedure, can thicken receding gums as well as a standard gum graft substitute (Alloderm). Twenty-four adults with at least 3 mm of gum recession on a front tooth will receive one of the two treatments. T…

This study tests whether toothpaste containing arginine, an amino acid, can prevent cavities in children aged 10 to 14. Participants brush twice daily with one of three strengths of arginine toothpaste or a standard fluoride toothpaste for one year. Researchers measure new caviti…

This study compares a new single-shade tooth-colored filling material, Omnichroma, to a standard multi-shade filling in children aged 3 to 5 years who have cavities in both upper front teeth. The goal is to see if the one-shade material can match the color of the surrounding toot…

This trial compares different bioactive restorative materials and placement techniques to see how they affect the health of the tooth's pulp (nerve) after treating deep cavities. Researchers will measure inflammatory markers in the fluid around the tooth and track post-treatment …

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop early cavities in molars as effectively as the standard treatment, a plastic coating called fissure sealant. Adults aged 20 to 45 with early, non-cavitated cavities will be randomly assigned to receiv…

This trial tests whether 3D-printed crowns work better than standard stainless-steel crowns for restoring damaged first permanent molars in children. The study will compare how well each crown holds up, its effect on gum health, and how satisfied children and parents are with the…

This study tests whether using hypochlorous acid—a mild disinfectant—during deep dental cleaning helps treat early-stage periodontitis (gum disease) better than cleaning with water alone. Researchers will measure gum healing, pocket depth, and inflammation markers in 44 adults wi…

This study compares two surgical techniques for treating gum recession: gingival unit grafting and conventional free gingival grafting. Researchers measure how well each graft matches the color of surrounding gum tissue and how much healthy gum tissue it adds over 18 months. The …

This trial tests whether using a low-power laser during a pulpotomy (removing infected pulp from a tooth) can improve healing and root formation in children aged 6 to 14 with painful, irreversible pulpitis in immature permanent molars. Participants receive either laser treatment …

This study tests whether a newer, easier-to-use material called NeoPUTTY works as well as the standard MTA for saving permanent back teeth with severe nerve inflammation in children aged 9 to 14. Both materials are used to cover the remaining healthy nerve after removing the dise…

This study tests two types of pit and fissure sealants (Fisseal and Prevent Seal) applied after treating teeth with one of two remineralizing agents (Biflourid or MI Paste). The goal is to see which combination best keeps the sealant in place and prevents cavities from forming or…

This study compares two types of dental implant attachments used in full-arch fixed dentures (All-on-4) for people with no teeth in the lower jaw. The OT-Bridge system is tested against standard multiunit abutments to see which leads to higher patient satisfaction and fewer prost…

This trial compares two types of rotary files (Kedo-Nano Plus and Kedo-S Square) with traditional hand files for root canals in children's baby molars. About 60 healthy kids aged 5-8 with infected molars will receive a pulpectomy using one of the three tools. Researchers will che…

This study compares a new 1% nanochitosan solution to standard nystatin oral suspension for treating Newton's type II denture stomatitis, a fungal infection causing redness and inflammation under dentures. The trial enrolls 30 complete denture wearers diagnosed by an oral special…

This trial tests three different ways of placing resin composite fillings in deep cavities to see which one causes the least irritation to the tooth's nerve (pulp). Adults with deep decay in their molars will receive one of the filling techniques, and researchers will measure inf…

This study tests two types of fluoride varnish—one that hardens with a special light and a standard one—to see if they can reverse white spot lesions (early cavities) that often appear after braces are removed. About 38 teenagers who are finishing orthodontic treatment will recei…

This study tests whether a new Sonicare power toothbrush head removes more dental plaque and reduces gum inflammation (gingivitis) than a standard manual toothbrush. About 100 adults with gingivitis will brush twice daily with either the power or manual brush for six weeks. Resea…

This trial tests whether placing a hyaluronic acid gel into the empty socket after lower wisdom tooth removal can prevent dry socket—a painful condition where the blood clot fails to form or is lost. The study includes 64 healthy adults who need a lower wisdom tooth extracted. Re…

This phase 3 study tests whether the drug ianalumab can reduce disease activity in people with active Sjogren's syndrome. About 275 adults with the condition will receive either ianalumab or a placebo shot under the skin. The main goal is to see if the drug improves symptoms and …

This trial tests whether specially framed text messages can improve oral health and quality of life in refugees living in Alexandria, Egypt. Participants receive either gain-framed messages (highlighting benefits of good oral care), loss-framed messages (highlighting risks of poo…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This trial tests whether adding a sticky bone graft to a standard gum flap procedure helps cover exposed tooth roots better than the flap alone. It includes 30 adults with mild-to-moderate gum recession. The study measures how much the gum covers the root and how thick the gum ti…

This study compares a new probiotic gel to a standard steroid gel for treating minor recurrent canker sores—painful mouth ulcers that make eating and talking difficult. Adults with these sores will apply either the probiotic or steroid gel four times daily for up to two weeks. Re…

This study tested a special drilling technique called osseodensification, which compresses bone instead of removing it, to prepare the jaw for dental implants. Twenty-three adults with missing teeth received about 40 implants using this method. The goal was to see if the techniqu…

This study tested three different materials used to treat severe, irreversible tooth inflammation. 72 adults with painful molars received a procedure where the damaged pulp was removed and covered with one of the materials. The goal was to see if newer materials (TheraCal LC and …

This study tested different application times (3 seconds to 2 minutes) of 38% silver diamine fluoride solution to see which works best for stopping cavities in preschool children. Over 600 healthy kids aged 3-5 with at least one cavity participated. Researchers checked if the cav…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This completed study tested a surgical technique called the combined bilaminar tunnel method for treating gum recession in patients with challenging tooth anatomy. Twelve participants received the procedure and were followed for six months. The goal was to see how much of the exp…

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This study tested a new surgical technique called the NORD flap for treating receding gums, comparing it to the standard method that uses a tissue graft from the roof of the mouth. The goal was to see if the new technique could cover exposed tooth roots just as well, with less pa…

This phase 2 trial tested a biologic drug called RC18 in 42 people with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants received weekly injections of either RC18 (at 160 mg or 240 mg) or a placebo for 24 weeks. The goal was to see if…

This study tested two types of dental fillings for cavities and tooth wear at the gum line in 20 professional ballet dancers. One filling was a ceramic-like material (PICN) and the other was a self-hardening composite. Over 24 months, the ceramic fillings had zero failures, while…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study tested a surgical technique for treating multiple receding gums. Twenty-one adults with gum recession on both sides of the mouth received a modified tunnel procedure with a connective tissue graft. The researchers compared two ways of placing the graft to see which gav…

This study tested two ways to treat receding gums: a new material made from the patient's own blood (T-PRF) and a standard connective tissue graft. Twenty healthy adults with gum recession on both sides of the mouth received both treatments, one on each side. The researchers meas…

This study looked at whether adding a surface sealant to a bulk fill dental filling helps it last longer and resist staining. 53 patients received three different fillings each, with or without a sealant. The fillings were checked every 6 months for 5 years to see if they failed,…

This study tested a chlorhexidine varnish applied to teeth in people with braces. Each person's mouth was split: one side got the active varnish, the other a placebo. Over 3 months, researchers measured gum overgrowth, plaque buildup, and early tooth decay (white spots). The goal…

This study tested whether a self-assembly peptide, with or without laser treatment, can help remineralize (repair) early cavities. Thirty adults with active early decay were treated and monitored for one year. The goal was to see if these approaches could reverse the early damage…

This study tested whether adding microneedling before standard gum surgery (coronally advanced flap) improves root coverage for people with thin gums and receding gums. Thirty-six adults with isolated gum recession on upper front teeth were randomly assigned to receive either mic…

This study tested whether a mouthrinse with benzydamine hydrochloride could reduce plaque buildup when people stopped brushing for three days. Fifty healthy women with no gum disease used either the active mouthrinse or a placebo. The results showed no significant difference in p…

This study tested whether toothpaste containing hops extract can reduce gum inflammation (gingivitis) better than standard fluoride toothpaste. 120 adults brushed twice daily for 3 months with one of four toothpastes. Researchers measured bleeding and gum health to see if the hop…

This study tested two materials, ProRoot MTA and Biofactor MTA, for direct pulp capping—a procedure to save a tooth's nerve after exposure. Eighty permanent teeth were treated, and patients reported pain levels for 48 hours. Success was checked at 6 and 12 months by looking for s…

This study tested a new type of ceramic crown that can be made and placed in a single dental visit, avoiding the need for temporary crowns. Fifty adults with decayed, fractured, or poorly filled molars or premolars received these crowns and were followed for up to five years. The…

This study tested whether a new mouthwash called MicroRepair ABX works as well as the standard chlorhexidine mouthwash for treating plaque-induced gingivitis (gum inflammation). Forty adults with gum disease used one of the two mouthwashes twice daily for 14 days after a professi…

This study tested different types of bulk-fill tooth fillings in 40 adults who had at least 4 cavities in their back teeth. The fillings were placed and then checked after 2 years to see how well they held up. The goal was to find out which filling material works best for treatin…

This study tested two types of dental crowns for children's back teeth: white zirconia crowns and traditional silver-colored metal crowns. Researchers treated 35 healthy kids aged 6-9 with cavities on multiple tooth surfaces. They checked how well each crown held up and asked par…

This study tested a new way to rebuild the lower jaw after removing benign tumors. Surgeons used virtual 3D planning to create custom-made plates and combined them with a piece of the patient's own rib bone. Thirty people took part, and the team checked how well the wounds healed…

This study tested four different mouthwashes—hydrogen peroxide with hyaluronic acid, hyaluronic acid alone, chlorhexidine, and a placebo—in 80 healthy adults aged 18 to 35 with mild gum inflammation. Participants used their assigned rinse twice daily for three weeks. The goal was…

This study tested whether injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), or hyaluronic acid gel can improve wound healing after gum surgery for overgrown gums. Sixty healthy adults were randomly assigned to one of four groups. Researchers measured…

This study looked at whether a special gel could help treat gum disease. Twelve adults with moderate gum disease received standard deep cleaning plus the gel. They also used the gel and a special toothpaste at home. After 8 weeks, their gum pockets and bleeding improved. The stud…

This study tested a porcine collagen matrix (Mucoderm) against the standard connective tissue graft for covering exposed tooth roots due to gum recession. Eighteen adults with gum recession on both sides of the mouth received one treatment on each side. The goal was to see if the…

This phase 2 trial tested darolutamide, a drug that blocks male hormones, in 57 people with a rare type of salivary gland cancer that has male hormone receptors. Some patients received darolutamide alone, while others also got goserelin to lower hormone levels. The goal was to se…

This study tested two types of ceramic dental restorations for teeth that have had root canal treatment: overlays and endocrowns. Twenty-five patients received one of the two restorations, and researchers checked how well they fit, any color changes at the edges, and how satisfie…

This trial tested a new dental cement called ALBO-MPCA in 20 adults with tooth decay. The cement is designed to stimulate the tooth to grow new dentin, the hard layer under the enamel. The goal was to see if it is safe and effective for repairing cavities and protecting the tooth…

This study tested a new material called Mucoderm, made from donated animal tissue, to treat receding gums. It compared it to the standard treatment, which uses a small piece of tissue from the patient's own palate. The goal was to see if Mucoderm could cover exposed tooth roots j…

This study tested whether a probiotic called Lactobacillus rhamnosus Lcr35® can reduce the number of painful canker sores in people who get them often. Twenty adults with frequent outbreaks took either the probiotic or a placebo daily for 3 months, then were monitored for another…

This study compared two types of dental crowns for children's baby molars: the standard stainless steel crown and a newer, tooth-colored BIOFLX crown. Researchers treated 36 children who had at least two decayed baby molars needing crowns. They checked the crowns after 1, 3, 6, a…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This study tested three cavity treatments in 60 children aged 4-8 years. Each child received all three treatments on different baby molars: the Hall Technique (a cap placed without drilling), silver diamine fluoride (a liquid that stops decay), and a standard tooth-colored fillin…

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study looked at the long-term safety of efgartigimod in 24 adults with primary Sjögren's syndrome who had already completed a prior trial. Efgartigimod works by lowering certain antibodies that may drive the disease. The main goal was to track side effects over 48 weeks, wit…

This completed Phase 1/2 trial tested whether metformin (a diabetes drug) and pirfenidone (an anti-scarring drug) can reduce fibrosis in people with oral submucous fibrosis, a condition that causes mouth stiffness and raises cancer risk. 45 participants received either metformin,…

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This study looked at whether giving radiation therapy after surgery can prevent early-stage oral cancer from coming back. It included 392 patients with tumors at least 5mm thick. Half received radiation, half were just watched. The main goal was to see if radiation reduced local …

This small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained f…

This study tested three different materials (blood clot, platelet-rich fibrin, and concentrated growth factor) combined with two types of rinses to help regrow root tissue in 30 immature permanent teeth with dead nerves. Participants aged 9 to 25 were followed for 12 months using…

This study tested whether transplanting pulp tissue from a healthy tooth into a dead one could restore vitality. Twenty-one adults with dead single-rooted teeth received either a pulp transplant, a pulp transplant with growth factors, or standard root canal treatment. The goal wa…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This pilot study tested whether applying prescription fluoride varnish to teeth every three months during the first year after radiation therapy for head and neck cancer can reduce cavities and gum problems. 13 adults with at least 4 natural teeth and certain cancers took part. T…

This extension study tested the safety and tolerability of two doses of iscalimab in 206 people with Sjögren's syndrome who had already completed a prior study. Participants received weekly injections for three weeks, then bi-weekly doses. The goal was to see if the drug is safe …

This Phase 2 study tested an experimental drug called SAR441344 in 84 adults with primary Sjögren's syndrome, a condition causing dry eyes, dry mouth, and fatigue. Participants received either the drug or a placebo by injection over 12 weeks. The goal was to see if the drug could…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This study looked at whether offering families extra support from a paediatrician and social worker after a child's dental surgery under anaesthesia helps them attend follow-up appointments and keep teeth healthy. 89 children with severe cavities took part. The goal was to see if…

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested whether painting a liquid called silver diamine fluoride (SDF) onto cavities every six months can stop tooth decay in young children aged 1.5 to 8 years. Some children also got a fluoride varnish every three months. The goal was to see if cavities become hard an…

Researchers compare two devices, Amy Check and Osstell, for measuring the stability of dental implants placed during a graftless closed sinus lift. The trial enrolls 30 adults who need tooth replacement in the upper back jaw and have limited bone height. Each participant receives…

Researchers are studying whether PET scans help doctors plan radiation more precisely for people with locally advanced head and neck cancer. Participants receive 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy, which shape beams to the tumor. T…

Researchers are studying whether cell-free RNA in saliva can work as a non-invasive liquid biopsy to help diagnose Sjögren's disease. The trial compares saliva from people with Sjögren's disease against saliva from people with dry-eye and dry-mouth symptoms who do not have the di…

Researchers are testing whether a fluorescent dye called cRGD-ZW800-1 can help surgeons see oral cancer tumors more clearly during surgery. The trial enrolls adults with squamous cell carcinoma of the mouth who are scheduled for tumor removal. Participants receive an injection of…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

Researchers are testing whether a handheld device that shines a special light on the inside of the mouth can help clinicians spot suspicious areas that might be precancerous or cancerous. The study will have three dentists with different levels of experience examine 200 adults, i…

This trial tests a device that uses a laser to scan the inside of the mouth and help detect pre-cancer and cancer. Currently, doctors rely on their eyes to decide where to take a biopsy, which can miss early signs. The device collects molecular information from the tissue, and th…

This study tests whether a special light-based scanner, called DIAGNOcam, can better detect early cavities between teeth when used with a dye. Researchers will compare this method to standard X-rays and a visual-tactile exam. The goal is to see if the dye improves the ability to …

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study develops and tests an artificial intelligence model that analyzes standard dental photographs to detect gum recession, classify its severity, and suggest treatment options. Researchers use images from adults with visible gum recession to train the AI and compare its ac…

This study evaluates how accurately the Root ZX3 electronic apex locator measures the working length of root canals in single-rooted teeth that need to be extracted. Researchers compare the device's measurements with microscopic measurements taken after extraction, which serve as…

This study tests whether a non-invasive imaging tool called swept-source optical coherence tomography (SS-OCT) can detect early signs of tooth erosion caused by acidic drinks. Twenty-two healthy adults swished orange juice repeatedly over three days, and their teeth were scanned …

This study tested whether a 3D cone-beam CT scan (a type of X-ray) can diagnose non-cancerous salivary gland diseases as well as MRI. Fifty adults with symptoms like swelling or pain in their salivary glands underwent both imaging methods. The goal was to see if the 3D-CBCT could…

This study tested whether a special light (autofluorescence) can help doctors spot early signs of mouth cancer in people who smoke and drink heavily. 180 adults hospitalized for alcohol withdrawal took part. The goal was to see if the light technique is more reliable than a stand…

This study tested an artificial intelligence (AI) algorithm designed to analyze images of minor salivary gland biopsies to help diagnose Sjogren's syndrome. Researchers used 1,000 biopsy samples from patients with suspected Sjogren's to see if the AI could accurately count immune…

This study tested four methods for finding early tooth decay in children aged 6 to 14. Researchers compared standard visual inspection with three special tools that use light or lasers. The goal was to see which method works best for spotting cavities that haven't yet formed a ho…

This study tested a new type of PET-CT scanner that can scan a tumor right after it is removed from the body. Patients with prostate or head and neck cancer received a small amount of radioactive tracer before surgery, which sticks to cancer cells. After removal, the specimen was…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

Researchers at two intensive care units in Budapest studied whether professional oral care and staff education improve oral hygiene in critically ill adults. Dentate patients were assigned to receive either professional cleaning by dentists three times a week or standard care fro…

Researchers are testing whether a toothpaste containing proteins, enzymes, and fluoride improves gum health and reduces plaque more than a standard fluoride toothpaste. The study enrolls healthy adults aged 18 to 70 with mild gum inflammation. Participants use one of the two toot…

Researchers at the University of Barcelona are testing whether a mouthwash made from bioflavonoids can reduce dental plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. The trial enrolls 24 adults with at least 20 teeth and no severe gum disease. Par…

Radiation for head and neck cancer often causes painful mouth sores called oral mucositis. Researchers are testing whether a probiotic, Lactobacillus rhamnosus GG, can prevent severe cases. The trial enrolls 160 adults with head and neck cancer who are scheduled for radiation. Ha…

This trial tests whether interactive dental health education—using games or peer groups—can improve oral hygiene, self-efficacy, and self-esteem in orphans aged 7 to 12. It compares these methods against a standard lecture-style session. The goal is to see if more engaging teachi…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested four different dental filling materials in 120 adults at high risk for cavities. The goal was to see if newer 'bioactive' materials could prevent secondary cavities (cavities that form around the edge of a filling) better than a standard composite resin. Partici…

This study tested three methods of keeping teeth dry while applying protective sealants to prevent cavities in children's permanent molars. Thirty children at high risk for cavities took part, and each method was compared for how long it took, how well the sealant stayed on after…

This study tested three early treatments—fluoride varnish, conventional sealant, and self-etch sealant—on 132 children's partially erupted permanent molars with early cavity signs. The goal was to see which best prevents cavities from forming or getting worse. Researchers tracked…

This study tested whether fluoride or probiotic toothpaste can prevent cavities in 508 children aged 4-5. Kids brushed twice daily for 12 months with either fluoride, probiotic, or plain toothpaste. Researchers also surveyed eating and brushing habits to find risk factors for cav…

This study tested whether sending WhatsApp messages that offer a discount or suggest scheduling a dental check-up on the same day as a medical appointment increases preventive dental care. Over 300,000 adults in Chile who had a medical visit coming up and hadn't seen a dentist in…

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This study tested whether giving kids a connected toothbrush and a behavioral health app after cavity surgery helps them brush better and lowers dental costs. 93 children aged 4-7 who had surgery for cavities used the smart toothbrush and received motivational texts. Researchers …

This study tested whether probiotic lozenges can prevent white spots (early cavities) that often appear around braces. 75 healthy people with braces took part. Some used probiotic lozenges, some used a control lozenge, and some had no extra treatment. The researchers measured new…

This study tested whether teaching parents about oral hygiene, diet, and fluoride can prevent early childhood cavities. One hundred parents of children aged 0-3 took part. The intervention group received structured education sessions with booklets and videos. The goal was to impr…

This study looked at three types of tooth sealants made from glass ionomer to prevent cavities in children's back teeth. Two hundred healthy kids aged 6 to 12 got sealants on their lower first molars and were checked over 24 months. The goal was to see which sealant stayed on bes…

This study tested whether having a dental assistant visit older adults at home every three months for professional cleaning and high-fluoride toothpaste could prevent root cavities. 194 home-living adults aged 65+ who needed daily care took part. The goal was to see if this appro…

This study tested whether dental interns can apply cavity-preventing sealants just as well after watching a video as after in-person training. Fifty children aged 7–9 each had two molars treated, one by each training method. After three months, the sealants placed by video-traine…

This study tested whether offering small financial rewards (like a drawing for a prize) could motivate parents to brush their young children's teeth more often. About 244 families with kids in Early Head Start programs took part. The goal was to see if the reward program increase…

Researchers are testing whether a topical melatonin gel helps dental implants stay stable when placed immediately into tooth sockets that had chronic infection. Sixty adults with non-restorable teeth and long-standing apical lesions will receive either standard implant placement …

Researchers at Hanoi Medical University are studying zirconia laminate veneers, thin tooth-colored shells that bond to the front of teeth. The trial enrolls 50 people with chipped, discolored, spaced, or mildly crowded teeth. The team measures how well the veneers fit, how health…

This study tests whether a special nano calcium fluoride varnish, a diode laser, or both together can reduce tooth sensitivity. Thirty adults with sensitive teeth will receive one of the treatments and rate their pain on a scale. The goal is to see which approach provides the bes…

Researchers compare two dental implant connection designs to see how each affects the bone around implants that hold lower dentures. Fourteen fully edentulous men, aged 45 to 60, receive two implants in the lower jaw, with one group getting internal tri-lobe implants and the othe…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

Researchers are testing whether showing adults with gingivitis personalized 3D images of possible future gum changes helps them brush and clean between their teeth more consistently. The study enrolls 88 adults aged 18 to 60 with gingivitis, divided into three groups. One group r…

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either c…

Researchers compare two root canal file systems, ProTaper Gold and ProTaper Ultimate, to see if they differ in how much pain patients feel afterward. The trial enrolls 40 adults with permanent lower molars diagnosed with symptomatic irreversible pulpitis and apical periodontitis.…

Researchers compare three sealers used during root canal treatment, Totalfil, NeoSealer, and AH-Plus, to see how much pain patients feel afterward. The study includes 39 people with painful, inflamed lower molars that need a root canal. Each participant receives one of the three …

Researchers compare two materials used in pulpotomy, a procedure that removes inflamed pulp from a tooth and covers the remaining tissue. Adults with deep cavities and signs of pulp inflammation in lower first or second molars receive either BIO MTA+ or Well-Root PT. The study me…

Researchers at Ataturk University are testing whether watching nature videos through virtual reality glasses can improve sleep quality and mental well-being in people with multiple sclerosis. The trial enrolls 42 adults aged 18 to 80 who have MS and are not in an attack. One grou…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This trial tests whether applying a phenytoin-loaded hydrogel to surgical wounds can improve healing after oral cancer surgery. Adults with locally advanced oral squamous cell carcinoma who are having surgery to remove the tumor will receive either standard wound care or standard…

This study tested whether injecting vitamins C or E into the gums could help teeth move faster during braces treatment. 51 patients received either vitamin C, vitamin E, or a placebo injection every two weeks to a month for six months. Researchers measured tooth movement, pain, a…

This study tests whether a mouthwash made from frankincense and coconut oil can help treat mild to moderate gingivitis (gum inflammation). Researchers will compare it to a standard commercial mouthwash in 90 adults over 21 days. The goal is to see if the natural blend reduces pla…

This study looked at how well BioFlx crowns work for fixing cavities in children's back teeth. Twenty-eight kids aged 6 to 9 got the crowns and were checked for up to 24 months. The goal was to see how the crowns held up and how happy the children and parents were with them.

This trial tests whether a bleaching gel fortified with tiny titanium oxide particles can whiten teeth better and cause less sensitivity than a standard gel. Sixty adults with tooth discoloration will receive either the nano-enriched gel or the conventional gel during a single se…

This study looked at whether applying ozone gas to surgical wounds in the mouth can help gums heal faster after gum surgery. Twenty-four people with enlarged gums due to chronic inflammation took part. Each person had two similar areas treated: one with standard surgery alone, an…

This study tests whether applying injectable platelet-rich fibrin (I-PRF) to the wound after gum surgery (gingivectomy or gingivoplasty) can improve healing. Twenty adults with chronic inflammatory gum overgrowth will be split into two groups: one gets standard surgery alone, the…

This study tests whether a special mouthwash can reduce gum inflammation (gingivitis) in adults. Thirty healthy volunteers with moderate gum redness and swelling will rinse daily for 4 weeks. Dentists will check their gums at the start and end to see if the product helps ease sym…

This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. …

This study tests a new toothpaste designed to reduce tooth sensitivity. About 850 people with sensitive teeth will brush twice daily for 8 weeks. Researchers will measure pain from air puffs and gentle touch to see if the new formula works better than other toothpastes.

This study looks at whether rinsing with a green tea extract (EGCG) during a tooth-saving procedure (pulpotomy) can lower pain and improve success rates in adults with severe tooth decay. 64 participants with deep cavities will receive one of two rinses and one of two filling mat…

This trial tests whether immersive virtual reality (VR) can reduce pain, dental fear, and improve cooperation in children aged 8-12 during restorative dental treatment. Half the children will watch an age-appropriate animated video through a VR headset during local anesthesia and…

This study tests whether wearing a virtual reality headset during dental procedures can reduce pain and anxiety compared to standard care. Adults needing similar fillings on both sides of their mouth will receive one side with VR distraction and the other without, allowing a dire…

This study tests whether a toothpaste designed for sensitive teeth can also improve oral hygiene and gum health in people with dentine hypersensitivity. Participants will use the toothpaste over time, and researchers will measure changes in tooth sensitivity, plaque buildup, and …

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This trial investigates whether placing a retraction cord—a thin thread that pushes the gum aside—during a tooth restoration affects gum health. Adults with non-carious cervical lesions (tooth damage near the gumline not caused by decay) will receive composite restorations either…

This trial tests whether two experimental mouthwashes can relieve dentinal hypersensitivity—sharp pain from hot, cold, or air on teeth. About 118 adults with sensitive teeth will use one of the mouthwashes or a placebo, either once or twice daily, for up to 8 weeks. Researchers w…

This trial compares a toothpaste with stannous fluoride against a popular potassium-based desensitizing toothpaste and a regular fluoride toothpaste. About 116 adults with sensitive teeth will brush twice daily for a week. The goal is to see if the stannous fluoride formula reduc…

This trial asks whether photobiomodulation — a type of low-level laser therapy — can lessen pain and swelling after endodontic (root-end) surgery. Thirty-four adults needing surgery on an upper tooth will be randomly assigned to receive either the laser treatment or a sham proced…

This trial tests whether sucking lemon candy and using honey mouthwash can reduce salivary gland damage caused by radioiodine therapy for thyroid cancer. About 120 adults who have had their thyroid removed and are about to receive radioiodine will be randomly assigned to the cand…

This study looks back at medical records of adults with head and neck cancer who developed painful mouth sores from radiation or chemotherapy. Researchers will compare how well laser therapy and ozone therapy eased those sores and reduced pain. The goal is to see if one approach …

This trial compares two irrigation solutions used during regenerative endodontic treatment for immature permanent teeth with infection. Forty children aged 9 to 16 will receive either octenidine or EDTA as a rinse, and their pain levels will be tracked for a week. The goal is to …

This trial tests whether warming up dental filling materials before placement can reduce inflammation inside the tooth and lessen pain after treatment. Thirty adults with deep cavities will receive fillings at different temperatures — one group gets a special flowable composite p…

This trial tests whether an all-in-one dental isolation system called Isolite is more comfortable for children than the traditional rubber dam during cavity treatment. Sixty-six kids aged 8 to 12 will try both methods in random order, and researchers will measure pain, comfort, a…

This trial tests two non-surgical injectable treatments for a gummy smile, where too much gum shows when smiling. Twenty adults with a gummy smile of 3 mm or more received either botulinum toxin (Botox) or a hyaluronic acid filler. The study measures how much the gum exposure is …

This trial compares two ways of giving the anti-inflammatory drug piroxicam to control pain after root canal treatment: a standard oral pill versus an injection into the ligament around the tooth. Adults with a toothache caused by irreversible pulpitis will receive one of the two…

This study tests whether using cooled liquid to clean the inside of a tooth during root canal treatment can reduce pain afterward. It includes adults with certain tooth conditions who need a root canal. The approach involves comparing cooled versus room-temperature irrigation to …

This trial compares two minimally invasive treatments—Antivet and Opalustre—for improving the appearance of mild enamel fluorosis, a condition that causes tooth discoloration. Adults aged 20 to 35 with mild fluorosis on their front teeth are randomly assigned to receive one of th…

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

Dental fluorosis can leave chalky white spots on front teeth, affecting appearance even when the enamel is intact. This trial compares two gentle treatments—resin infiltration and enamel microabrasion followed by a calcium-phosphate paste—for masking those spots. Researchers meas…

This study tests whether a paste made from chitosan nanoparticles can heal minor mouth ulcers and reduce pain better than a standard steroid ointment. Thirty people with recurrent aphthous stomatitis (canker sores) will apply either the chitosan paste or the steroid paste to thei…

This study looked at two treatments for oral lichen planus, a chronic mouth condition that can cause pain and change how food tastes. Researchers compared a light-based treatment (photodynamic therapy) with steroid cream in 65 adults. They measured taste ability, pain, and lesion…

This study tests whether taking ibuprofen before a root canal can improve the effectiveness of local anesthesia in people with severe tooth inflammation (irreversible pulpitis). Participants will receive either ibuprofen or a placebo before the procedure, and pain levels will be …

This study compares three treatments for recurrent aphthous stomatitis (canker sores): St. John's wort oil, a topical corticosteroid, and hyaluronic acid gel. Researchers measure how well each reduces pain, shrinks ulcer size, and speeds healing in adults with a history of these …

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tested two ways to whiten teeth: a chemical bleaching gel and a light-activated bleaching gel. Thirty adults with yellowish or brownish stains on their front teeth were randomly assigned to one of the two methods. Researchers measured how white teeth got, how much toot…

This study tested whether dissolvable mineral-loaded starch strips can quickly relieve dentin hypersensitivity, a common condition causing sharp pain from hot, cold, or touch. 82 adults with sensitive teeth used either the strips or a Novamin toothpaste. The goal was to see if th…

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer typ…

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study tested four approaches for treating dentine hypersensitivity (tooth sensitivity): Nd:YAG laser, diode laser, a herbal propolis-based gel, and a sham (fake) treatment. 140 adults with at least two sensitive teeth were followed for 12 months to see which method reduced p…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study looked back at medical records of 58 adult cancer patients who developed painful mouth sores from chemotherapy or radiation. They had been treated with a combination of ozone applied in the dentist's chair and ozone-based gels, toothpaste, and mouthwash at home. The go…

This study tested whether using an ultrasonic device to clean root canals causes less pain afterward than a standard needle. 108 adults with tooth pain had root canals and were randomly assigned to one method. Pain was measured using a scale. The goal is to find which cleaning me…

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This study tested whether a smartphone app designed for patients having gallbladder removal surgery could reduce anxiety, complications, and improve comfort and satisfaction. 64 adults scheduled for laparoscopic cholecystectomy used the app during their hospital stay and recovery…

This study tested two treatments for tooth sensitivity: a special varnish and an air-polishing system. Thirty adults with sensitive teeth were treated, and researchers measured pain relief and any tooth color changes. The goal was to find which method works better for easing disc…

This study tested whether a special tooth gel can help adults with sensitive teeth. Thirty-one participants used the gel three times a day for two weeks. Researchers measured pain from cold air and touch before and after treatment to see if sensitivity improved.

This study tested whether a desensitizing toothpaste, used alone or with a mouthwash, can reduce tooth sensitivity in adults. 71 participants used the products daily for 14 days. Researchers measured changes in sensitivity to see if the toothpaste worked better than regular tooth…

This study tested whether a propolis mouth rinse could delay or prevent severe oral mucositis (painful mouth sores) in 140 head and neck cancer patients undergoing radiation. Participants used either a 15% propolis solution or a placebo four times daily alongside standard oral ca…

This study looked at whether using a special laser (diode laser) after a common dental procedure called direct pulp capping can help reduce pain and tooth sensitivity. Fifty-six people with tooth decay that reached the nerve were treated. Half got standard care, and half got stan…

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested whether waiting 2 days or 7 days between in-office teeth whitening sessions affects tooth sensitivity. 47 adults with dark teeth received two bleaching sessions using a 35% hydrogen peroxide gel. Their pain levels were recorded for 48 hours after each session, a…

This study looked at whether a nose spray medicine called midazolam can help calm preschool children (ages 2-6) before they have surgery to remove their tonsils and adenoids. The goal was to make the children less anxious and more comfortable before anesthesia. The study included…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested three biocompatible materials—TheraCal PT, Biodentin, and MTA—for reducing pain after a pulpotomy (removing the inner pulp) in 51 adults with severe toothache. Participants rated their pain before and up to 7 days after treatment. The goal is to find which mater…

This study tested whether a mouth rinse made from sumac, a common spice, can help heal painful canker sores and reduce pain. Thirty-eight healthy adults with minor mouth ulcers used the rinse and were monitored for healing and pain levels. Researchers also measured inflammation m…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet …

This study tested if zinc oxide ointment can help heal painful canker sores. One hundred people with canker sores used either the zinc ointment or a placebo three times a day for six days. Researchers measured pain and how the sores affected daily life to see if the ointment made…

This study tested a mineral mouth rinse (THERAVEX®) in 116 adults with primary burning mouth syndrome, a condition causing ongoing mouth pain. Participants rinsed with the mineral solution or a placebo for 8 weeks. The main goal was to see if the rinse reduced burning pain intens…

This study compared two common painkillers—diclofenac sodium and ibuprofen—for managing pain after a root canal. Sixty adults with irreversible pulpitis received one of the two drugs right after treatment, and their pain was tracked for 48 hours. The goal was to see which drug pr…

This study compared two ways to fill a root canal after treating a painful tooth infection (irreversible pulpitis). 56 people aged 18-60 took part. One group got a continuous wave condensation filling, the other a single-cone filling. Researchers measured how long each method too…

This study tested a new dental filling material against a standard one to see which looks better. 36 adults with cavities in their front teeth each got both fillings. Researchers measured patient satisfaction with the appearance using a scale. The goal was to see if the new mater…

This study tested a new device that uses high-voltage electric pulses to shrink enlarged tonsils without cutting. Twenty-four adults with grade 2 or higher tonsil hypertrophy received the treatment. The goal was to reduce tonsil size and pain, with results measured at 3 months.

This study tested whether giving children montelukast before and after tonsillectomy reduces their pain and need for strong painkillers. 116 kids aged 3-8 took part, receiving either montelukast or a placebo. Researchers measured pain scores and how often families contacted docto…

This study tested whether taking a specific probiotic (Limosilactobacillus reuteri) can improve gum health in adults with braces who also have gingivitis (gum inflammation). One hundred participants either received the probiotic or no supplement. Researchers measured gum bleeding…

This study tested two ways to treat early white spot lesions on teeth in 30 teenagers aged 12 to 18. Each participant received both a resin infiltration and a microabrasion treatment on different teeth to see which worked better. The goal was to improve the appearance and stop th…

This study tested two mouthwashes—a standard antiseptic (chlorhexidine) and a new one (MicroRepair ABX)—in 40 adults with gingivitis (gum inflammation). After a professional cleaning, participants used their assigned mouthwash twice daily for 14 days. Researchers measured gum ble…

This study tested whether listening to personally chosen music can reduce pain and anxiety during dental drilling. Thirty adults picked a relaxing song and had their heart rate, blood pressure, and pain levels measured with and without music. The goal is to see if music can be a …

This study tested a home-use light device and special mouth rinse to help people with oral lichen planus, a painful mouth condition. Thirteen participants used the device daily for a year alongside standard care. The goal was to see if it could reduce pain and inflammation better…

This study tested whether a new 2-in-1 foam toothpaste and mouthwash (Scigates) can reduce tooth sensitivity and whiten teeth better than a standard toothpaste. Fifty-seven adults with mild staining and sensitive teeth used either the Scigates product or a control toothpaste thre…

This study looked at 146 adults with painful tooth inflammation who needed root canal treatment. It compared two different tools (WaveOne and ProTaper) to see which one leads to less pain after the procedure. Patients rated their pain at several times over a week. The goal is to …

This study tested a resin coating on the front teeth of 40 children aged 7-14 who had weak enamel (hypomineralization or hypoplasia) and tooth sensitivity. The treatment aimed to reduce pain from cold air and improve how kids and parents felt about the look and function of their …

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study looked at whether regular aerobic exercise, like walking, can reduce fatigue in women with primary Sjögren's syndrome. Forty-five women participated in a 16-week program. Researchers measured changes in fatigue, mood, and physical fitness.

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were mea…

This study tested whether placing orange blossom essential oil inside a stoma bag can reduce odor, lessen social isolation, and help people adapt to life with a stoma. Sixty adults with a stoma took part. Researchers measured changes using a stoma adaptation scale and a social is…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested whether vitamin B12 tablets can ease painful mouth ulcers caused by braces, comparing them to a standard steroid gel (Kenalog). 82 adults with traumatic ulcers were split into two groups. Researchers measured pain and ulcer size after 4 and 8 days to see which t…

This study looked at whether acupuncture can reduce dry mouth (xerostomia) caused by radiation therapy in people with head and neck cancer. A total of 258 participants were randomly assigned to receive acupuncture or usual care. The main goal was to see if acupuncture improved dr…

This study tested four different anesthesia drugs in 100 children aged 3-10 having tonsil surgery. The goal was to see which drug best prevents confusion and restlessness after waking up. Researchers measured pain, agitation, and recovery quality in the recovery room.

This study tested whether a nightly warm foot bath can reduce fatigue in children aged 7-12 with lymphoma who are undergoing chemotherapy. Sixty children took a 20-minute foot bath at 38-40°C for 7 days. The goal was to see if this simple, non-drug approach could improve their en…

This study tested two treatments for tooth sensitivity: a special toothpaste with bioactive glass and a low-level laser. 100 adults with sensitive teeth were randomly assigned to one of these treatments or a placebo. The goal was to see which approach provides better and longer-l…

This study looked at 120 people who needed root canal treatment on their molars. Researchers tested different filling materials (bioceramic vs. resin-based) and techniques (cold vs. warm filling) to see which caused the least pain afterward. The goal is to help dentists choose op…

This study tested whether using a diode laser along with a potassium nitrate gel (a desensitizing toothpaste ingredient) works better than the gel alone for treating sensitive teeth. Twenty-three adults with tooth sensitivity received either the real laser plus gel or a sham lase…

This study tested two ways to remove bone during a minimally invasive sinus surgery called the prelacrimal approach. One method uses a modern ultrasonic device (piezosurgery), the other uses a traditional hammer and chisel. The trial included 40 adults with various non-cancerous …

This study tested whether a selenium gel can help treat oral lichen planus, a chronic condition that causes painful sores in the mouth. Fifty adults with the condition used either selenium gel, a standard steroid cream, or an immunosuppressant cream. The goal was to see if seleni…

This study tested whether a low-level laser can be used to treat painful mouth sores caused by chemotherapy or radiation in children with cancer. The laser was applied to the inside of the mouth every two days while sores were present. The main goal was to see if the treatment co…

This study tested whether a warm water foot bath (38-40°C for 10 minutes) can help manage fever and pain in children aged 1-5 who came to the emergency room with a fever of 38.3°C or higher. All 60 children also received standard paracetamol. The goal was to see if the foot bath …

This study tested two ways to remove extra gum tissue (gingival hyperplasia) in people with braces: using a surgical scalpel or a diode laser. Thirteen adults with fixed braces and gum overgrowth took part. The goal was to see which method led to better healing, less pain, and im…

This study tested whether photodynamic therapy (PDT) — a light-activated disinfection method — can reduce pain after root canal treatment. 95 adults with infected back teeth received either standard cleaning or PDT-enhanced cleaning. Researchers measured pain levels and painkille…

This Phase 3 study tested cenegermin (Oxervate) eye drops against a placebo in 85 adults with severe dry eye caused by Sjogren's syndrome, who were already using cyclosporine drops. The goal was to see if cenegermin could increase tear production and reduce eye discomfort over 4 …

This study tested whether carving the retromolar pad area on lower dentures improves satisfaction and quality of life for new denture wearers. Fifty adults with no teeth and no prior denture experience each tried both a carved and a non-carved lower denture. Researchers measured …

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days.…

This study tested whether using computer-based virtual planning before jaw reconstruction surgery improves patients' quality of life compared to standard surgery. 132 adults with oral or oropharyngeal cancer who needed a fibula free-flap reconstruction took part. The main goal wa…

This study tested two treatments—laser therapy and ozone gas—to relieve painful mouth sores caused by cancer treatment. Forty adults with head and neck or blood cancers took part. Each received one treatment daily for five days. The goal was to see which therapy better reduced so…

This study tested whether gargling with hawthorn vinegar, black mulberry syrup, or green tea could improve oral health and quality of life in 120 adults with diabetes who had mouth sores (mucositis). Participants used one of the three gargles three times a day for 14 days alongsi…

This study looked at whether a gel containing amitriptyline, applied inside the mouth, could reduce pain in people with burning mouth syndrome. Researchers reviewed records of 30 adults who used the gel for several weeks. They measured pain levels before and after treatment and n…

This study tested a steroid nasal spray (mometasone furoate) in 130 children aged 3-12 who snore and have sleep-disordered breathing. The goal was to see if the spray could relieve symptoms enough to avoid surgery to remove tonsils or adenoids. Children used the spray daily for 6…

This study tested five different devices for giving numbing shots in the roof of the mouth (palate) to 200 healthy adults having a molar pulled. The goal was to see which device caused the least pain and fear during the injection. Researchers measured pain, fear levels, and heart…

This study tested whether a toothpaste and mouthwash made with biomimetic hydroxyapatite could reduce tooth sensitivity in 100 adults with receding gums. Participants had one 30-second application of either the toothpaste or mouthwash in a clinic. Sensitivity was measured before …

This study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complicat…

This pilot study tested a device that gently stimulates the inside of the nose to see if it can improve tear production in people with Sjogren's syndrome. 26 participants used either the active device or a sham (fake) device for 6 weeks, then everyone used the active device for a…

Researchers measure levels of the protein periostin in the blood and adenoid tissue of children with enlarged adenoids. They compare children scheduled for adenoid removal with children who have only mild enlargement and no symptoms. The study asks whether periostin is linked to …

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

Researchers at Gazi University are studying whether Behçet's disease, which causes mouth sores and eye inflammation, is connected to gum disease. They compare 40 people with Behçet's plus gingivitis or periodontitis against 47 people with gum disease alone. The team measures infl…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study looks at whether children with a condition called molar incisor hypomineralization (MIH), which causes weak enamel on molars and front teeth, experience more stress during dental checkups. Researchers will measure stress by testing saliva for cortisol and checking hear…

This trial tests four ways of making upper denture bases to see which fits the mouth most accurately. Thirteen adults with no teeth in their upper jaw receive dentures made by conventional molding, fully digital 3D printing, and two hybrid methods. Researchers scan each denture a…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looks at tissue samples from 34 people with oral squamous cell carcinoma to measure levels of a protein called cyclin D1, which helps cells divide. The goal is to see whether higher cyclin D1 levels are linked to patient age, sex, tumor location, grade, or signs of inv…

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivit…

This trial compares two different sequences of nickel-titanium (NiTi) archwires used in braces to see which one aligns teeth faster, causes less discomfort, and leads to less root shortening. It involves 60 people aged 12-35 who need full orthodontic treatment for crowding. Parti…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looked at how gum tissue heals when taken from two different areas of the palate (roof of the mouth) to treat receding gums. Forty healthy adults aged 20-40 had a gum graft taken either from the front or back of the palate. Using 3D scans, researchers measured volume c…

This trial asks whether two common cleaning methods—mechanical polishing with a paste or applying a 35% hydrogen peroxide gel—change the readings of a laser device (DIAGNOdent) used to spot early tooth decay on the chewing surfaces of back teeth. In each participant, one side of …

This study looks at how gum disease, from mild gingivitis to more severe periodontitis, changes the activity of certain genes and proteins involved in inflammation and cellular cleanup. Researchers will collect small gum tissue samples from people with healthy gums, gingivitis, o…

This study investigates whether stress inside gum cells plays a role in periodontal disease, which causes inflammation and damage to the tissues supporting the teeth. Researchers measured markers of cell stress and inflammation in fluid and tissue samples from 72 non-smoking adul…

This study looks at why gum disease (gingivitis) develops at different rates in different people. Healthy adults aged 18 to 35 will stop brushing and flossing for 3 weeks to allow mild gum inflammation to develop, then resume normal hygiene to recover. Researchers will take clini…

This study investigates whether specific proteins involved in inflammation are present at different levels in people with healthy gums, gingivitis, or periodontitis. Researchers will collect saliva, gum fluid, and gum tissue samples from 75 adults and measure the levels of these …

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study tests whether ultrasound can map blood vessels in the lower jaw before gum recession surgery. Four adults with gum recession will receive a coronally advanced flap procedure, and researchers will compare ultrasound images taken before surgery with what they see during …

This study aims to discover new genes and mutations that cause isolated forms of amelogenesis imperfecta and dentinogenesis imperfecta—inherited conditions that affect tooth enamel and dentin. Researchers are using whole exome sequencing on participants who have these tooth disor…

This study looks at two different ways clear aligners are trimmed—one that sits on the gums and one that stops at the gum line—to see which leads to less plaque and healthier gums. Twenty adults with mild to moderate crowding will wear both designs at the same time (one on top, o…

This study investigates how gum disease—from mild gingivitis to severe periodontitis—affects specific proteins inside gum tissue cells that help control cellular cleanup and communication. Researchers will collect small gum samples from people with healthy gums, gingivitis, or pe…

This study looks at whether certain genetic variations (in COMT, MAOA, and SLC6A4) influence how well a standard dental numbing injection works for people with a painful tooth condition called irreversible pulpitis. Participants received a numbing shot and had their pain levels m…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study examines how different types of bacteria in the mouth are linked to the severity of dental cavities. Researchers will collect saliva and plaque samples from 56 people aged 3 to 45 and grade their cavities using a standard scoring system. The goal is to better understan…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study tested three ways to teach oral hygiene to 72 teenagers with braces: verbal instructions, a pamphlet, or a video. Researchers measured plaque and gum health before and after to see which method worked best. The goal is to find the simplest, most effective way to help y…

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This study tested two types of magnetic attachments (flat vs. dome-shaped) for lower dentures held by implants. Fourteen adults with no teeth in their lower jaw took part. The goal was to see which design keeps dentures more securely in place.

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …

This study examined 180 adults to see if the shape of their gums and their oral habits (like brushing force or teeth grinding) are linked to non-carious cervical lesions — wear on teeth not caused by cavities. Participants filled out a questionnaire and had a dental exam. The goa…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This study looked at whether a remote dental exam (teledentistry) can accurately assess treatment needs and behavior guidance for preschool children compared to a standard in-person exam. Researchers included 29 healthy children aged 4 to 6 years. The goal was to see if teledenti…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study tested whether taking common painkillers like paracetamol or ibuprofen before a dental pulp sensitivity test changes the results. 184 healthy adults received either a painkiller or a placebo, and their tooth nerve responses were measured. The goal is to help dentists a…

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain dur…

This study looked at how three types of dental crowns (stainless steel, zirconia, and fiber-glass) affect the gums of 21 children aged 6-9. Researchers measured gum pocket depth, bleeding, plaque, and inflammation markers in the gum fluid. The goal was to see which crown material…

This small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This study looked at 36 adults with painful tooth nerve inflammation (irreversible pulpitis) to see if biological markers in gum fluid match symptoms. Researchers collected gum fluid samples before and after root canal treatment and measured pain levels. The goal was to find a li…

This study tested two ways of placing a flowable bulk fill composite in class II cavities (fillings between back teeth). 38 patients received two fillings each, one with the flowable composite exposed at the edge and one not. Researchers will check for restoration loss, staining,…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at whether training health workers and actively reaching out to smokers and heavy drinkers aged 35+ can get more of them to have a simple mouth exam for early oral cancer detection. Over 1,100 people from Rio de Janeiro's primary care clinics took part. The goal…

This study compared five different membranes used to preserve the jawbone after a tooth is pulled. Bone loss after extraction is common, and membranes help protect the area for future dental implants. Researchers measured bone changes and tissue quality in 47 adults who needed a …

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This study looked at whether adding hands-on simulation training to standard classroom teaching helps nurses cause fewer problems when inserting needles into the arm access (arteriovenous fistula) of dialysis patients. About 9600 adults on chronic hemodialysis took part. The goal…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This study looked at 24 people getting braces or clear aligners to see which leads to more early tooth decay (white spots and hidden cavities). Over 6 months, researchers checked teeth with visual exams and a special scanner. The goal is to help patients and dentists choose the s…

This completed trial compared two ways of preparing the bone for dental implants: a newer technique called osseo-densification, which compacts bone rather than removing it, and the standard conventional drilling method. Eight adults needing two implants each (16 total) received o…

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This study looked at the types of bacteria in the mouth and the levels of a protective antibody in the saliva of children with autism, aged 6 to 18. Researchers collected dental plaque and saliva samples to compare with dental health. The goal was to learn more about oral health …

This study tested whether a microteaching approach improves nursing students' urinary catheterization skills and satisfaction compared to standard training. Sixty nursing students were randomly assigned to either microteaching or usual instruction. Researchers measured skill leve…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked back at 420 patients who had jaw surgery after using either clear aligners or traditional metal braces. The goal was to see if the type of orthodontic preparation affected how smoothly the surgery went. Researchers checked things like how stable the jaw was duri…

This study looked at how often people with primary Sjögren's syndrome have digestive issues. Researchers asked 151 patients about 10 different digestive symptoms using a simple questionnaire. The goal was to understand which symptoms are most common and how they relate to how lon…

This completed trial tested a mobile app and web platform (BD4QoL) to monitor quality of life in 410 head and neck cancer survivors after curative treatment. The goal was to see if the platform could reduce or catch early declines in quality of life compared to standard follow-up…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study explored whether the Epstein-Barr virus (EBV) contributes to inflammation in oral lichen planus, a chronic mouth condition that can be painful. Researchers measured levels of EBV genetic material in 13 adults with the atrophic or erosive form of the disease. The goal w…

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek sw…

This study tests a French version of a questionnaire that measures how dentin hypersensitivity (sharp, brief tooth pain) affects people's daily lives. Researchers enrolled 216 adults across three centers in France, including people with different levels of sensitivity and a contr…

This study looked for gene changes that might make children more prone to severe tooth decay. Researchers compared 390 young people with many cavities to cavity-free adults. They checked for mutations in genes that affect enamel, the hard outer layer of teeth. The goal is to unde…

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This study looked at 105 babies born to mothers who smoked during pregnancy, comparing those whose mothers quit versus those who continued. Researchers checked health indicators like birth weight, Apgar scores, and developmental milestones up to 24 months. The goal is to understa…

This study brings together 35 healthcare professionals from around the world to agree on the best methods for clearing mucus from the airways of intubated, critically ill patients. Using a Delphi process, experts will vote on statements about humidification, inhaled therapies, su…

This study tested whether using a laser for oral biopsies causes less pain and heals better than the standard punch scalpel in people with oral lichen planus. 112 adults were randomly assigned to one of the two methods. Researchers measured wound healing and discomfort after the …

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …

This study looked at 50 people who had a type of jaw cyst called an odontogenic keratocyst removed using different surgical methods. Researchers tracked how long it took for the bone to heal and whether the cyst came back over 10 years. The goal was to find out which surgical app…

This study examined whether certain gene variations (FCGR2A and FCGR3A) influence how well the drug cetuximab works in people with advanced upper aerodigestive tract cancers that have spread or come back. Researchers analyzed blood samples from 121 participants to look for these …

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study aimed to understand the different types of young children who get early cavities and what factors are linked to more severe decay. Researchers examined 298 children under 6 with early caries and surveyed their parents about dental knowledge, habits, stress, and social …

This study looked at 36 adults who needed gum graft surgery to see how their anxiety before the procedure affected their quality of life and pain during the first month after surgery. Researchers measured anxiety levels and asked patients daily about their oral health and comfort…

This study looked at 40 people with tooth inflammation (reversible or irreversible pulpitis) to see if certain immune markers in the blood (IL-8 and IL-10) could predict how well a tooth-saving treatment (vital pulp therapy) works. Participants received the therapy, and researche…

This study looked at 27 adults with Sjögren's syndrome to find out how common jaw joint problems (TMD) are and if they relate to disease activity. Researchers measured jaw function, mouth opening, head posture, and oral health. The goal was to better understand the link between S…

This study tested whether a 30-minute interactive lesson could improve dental interns' understanding of Molar-Incisor Hypomineralization (MIH), a condition that causes weak spots on teeth. Two hundred dental interns from Future University in Egypt took a quiz before and after the…

This study followed 240 people with head and neck cancer to see how their swallowing changed from diagnosis to 18 months after their first treatment. Researchers used a questionnaire called the Deglutition Handicap Index (DHI) to measure patients' own experience of swallowing pro…

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…