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Probiotic lozenges may stop Braces-Related tooth stains

NCT ID NCT05738369

Prevention Sponsor: Jordan University of Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether probiotic lozenges can prevent white spots (early cavities) that often appear around braces. 75 healthy people with braces took part. Some used probiotic lozenges, some used a control lozenge, and some had no extra treatment. The researchers measured new white spots, their size, and mineral loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Feb 2022

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

17 to 33 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy patients from both sexes * Having full fixed orthodontic appliances with expected remaining treatment duration of at least 6 months * Optimum oral hygiene * Maximum of 3 restored teeth * Absence of defective enamel formation in the form of hypocalcification or hypoplasia Exclusion Criteria: * Patients with poor oral hygiene * Defective enamel * Extensive restorations * Gingival hyperplasia * Salivary glands diseases * Smoking, alcohol consumption, mouth wash use, antibiotic or probiotic intake in the last 3 months.

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Conditions

The condition(s) this trial relates to.

enamel caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesion

Contacts and locations

Locations

  • Postgraduate Dental Teaching Clinics/JUST

    Irbid, 22110, Jordan

More trials for these conditions

Other studies related to the condition(s) this trial covers.