Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Battle of the white spot busters: paste vs. resin for Post-Braces cavities

NCT ID NCT05733676

Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study involves 62 people aged 12–21 who have at least one white spot after orthodontic treatment. Researchers will track how well each treatment stops the lesion from progressing and improves its appearance over 18 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MI Paste Plus (casein phosphopeptide-amorphous calcium phosphate with fluoride) and resin infiltration (Icon)
What this could lead to
If one treatment proves clearly better, dentists may have a more effective, esthetic option to reverse early cavities after braces, reducing the need for fillings.
What could go wrong
This is a small, early-stage trial with only 62 participants. Results may not apply to everyone, and long-term effects beyond 18 months are not studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 21 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals in the age range of 12-21 years who had undergone fixed orthodontic appliance therapy for a duration of 12-36 months. * Should have at least one white spot lesion on the labial surface of either maxillary or mandibular anterior teeth after debonding. Lesion visible with or without drying the lesion surface. * Patients with mild to moderate plaque accumulation. Fair oral hygiene. With a simplified Oral Hygiene Index of no more than 1.3-3.0 Exclusion Criteria: * Poor oral hygiene Simplified Oral Hygiene Index of 3.1-6.0 or more * Patients with hypoplasia or any developmental defects on the buccal of upper or lower incisors * Patients with any restorations on the buccal of upper or lower incisors * Patients that have presented WSL on the buccal of upper or lower incisors before orthodontic treatment was initiated. * Patients that have received any re-mineralizing agent other than regular toothpaste during the last three months * Patient with allergy to milk or any of their products * Patient with any medical / oral or mental condition * Patients or legal guardians that does not speak or read English

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Caries arrested are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

cardiac arrest enamel caries smooth surface dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries arrested Orthodontic appliance complication Smooth surface caries White spot lesions

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • KAYE Edmonton Clinic

    RECRUITING

    Edmonton, Alberta, T6G 1Z1, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.