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Fluoride varnish may shield teeth from white spots during aligner therapy

NCT ID NCT07319884

Prevention Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether applying fluoride varnish to teeth can prevent white spot lesions in people undergoing clear aligner treatment. Twenty-five participants aged 16 to 24 with mild crowding will have one side of their mouth treated with fluoride varnish and the other side left untreated. After six months, researchers will compare the number and severity of white spots between the two sides.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluoride varnish
What this could lead to
If it works, this could point toward a simple way to prevent white spots on teeth during clear aligner treatment.
What could go wrong
This is a small, early study with only 25 participants, so results may not apply to everyone. The treatment is applied to teeth and is generally safe, but some people may be allergic to fluoride.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Jun 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 24 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients aged 16-24 years. * Good general and oral health. * Mild dental crowding per arch (≤ 4 mm). * Eruption of all permanent dention excluding third molar Exclusion Criteria: * Allergy to fluoride material * Systemic conditions affecting tooth movement (e.g., diabetes, bone disorders). * Patients with Cleft lip and palate * Previous orthodontic treatment * dental fluorosis. * hypocalcified teeth or visible demineralization

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Conditions

The condition(s) this trial relates to.

enamel caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesion

Contacts and locations

Locations

  • Faculty of dentistry Mansoura University

    Al Mansurah, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.