Fluoride varnish may shield teeth from white spots during aligner therapy

NCT ID NCT07319884

Ongoing Prevention Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether applying fluoride varnish to teeth can prevent white spot lesions in people undergoing clear aligner treatment. Twenty-five participants aged 16 to 24 with mild crowding will have one side of their mouth treated with fluoride varnish and the other side left untreated. After six months, researchers will compare the number and severity of white spots between the two sides.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoride varnish
What this could lead to: If it works, this could point toward a simple way to prevent white spots on teeth during clear aligner treatment.
What could go wrong: This is a small, early study with only 25 participants, so results may not apply to everyone. The treatment is applied to teeth and is generally safe, but some people may be allergic to fluoride.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

enamel caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WHITE SPOT LESION

Contacts and locations

Locations

Faculty of dentistry Mansoura University

Al Mansurah, Egypt

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Other studies related to the condition(s) this trial covers.