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Could a Blood-Derived injection help gums heal faster after surgery?

NCT ID NCT07174934

Symptom relief Sponsor: Faculty of Dental Medicine for Girls Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This study tests whether applying injectable platelet-rich fibrin (I-PRF) to the wound after gum surgery (gingivectomy or gingivoplasty) can improve healing. Twenty adults with chronic inflammatory gum overgrowth will be split into two groups: one gets standard surgery alone, the other gets surgery plus I-PRF. Researchers will measure healing and patient satisfaction over 21 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (I-PRF)
What this could lead to
If it works, this could offer a simple way to improve gum healing after dental surgery.
What could go wrong
This is a very small early-stage trial with only 20 participants, so results may not apply widely. The treatment is experimental and may not speed healing as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Oct 2025

Finished

Jun 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1- Systemically healthy patients. 2- patients ages18-35years. 3- patients with chronic inflammatory gingival overgrowth. 4- patients with fibrotic gingival overgrowth. 5- Patients with enough attached gingiva. 6- Patients signing informed written consent. Exclusion Criteria: \- 1) Pregnancy or lactation. 2) Any known systemic disease. 3) Any type of previous periodontal treatment (surgical or non-surgical) in the preceding 6 months. 4\) smokers and alcohol users 5) clinical attachment or bone loss. 6) Patients run on immunosuppressive agents, systemic corticosteroids, chemotherapy, and/or radiotherapy drugs taken or prescribed 2 months before the study attempt, which may affect the study results, wound healing, and coagulation mechanism.

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Conditions

The condition(s) this trial relates to.

gingival overgrowth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic inflammatory gingival enlargement

Contacts and locations

Locations

  • Out-Patient Clinic of Oral Medicine, Periodontology, Oral Diagnosis and Radiology department, Faculty of Dental Medicine for Girls, Al-Azhar University.

    Cairo, Egypt

More trials for these conditions

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