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Could ozone gas be the secret to faster gum healing?

NCT ID NCT07517328

Symptom relief Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This study looked at whether applying ozone gas to surgical wounds in the mouth can help gums heal faster after gum surgery. Twenty-four people with enlarged gums due to chronic inflammation took part. Each person had two similar areas treated: one with standard surgery alone, and the other with surgery plus ozone gas applied for one minute per tooth. Researchers checked healing using cell samples and gum health measurements over three weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gaseous ozone
What this could lead to
If it works, this could offer a simple, low-cost way to speed up gum healing after surgery and reduce discomfort.
What could go wrong
This is a small, early-stage study with only 24 participants. The results may not apply to everyone, and ozone therapy is not yet a standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

May 2016

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy individuals * Patients diagnosed with chronic inflammatory gingival enlargement * Presence of gingival enlargement affecting the maxillary or mandibular anterior region * Symmetrical involvement of at least six teeth * No clinical attachment loss * Ability to maintain adequate oral hygiene following non-surgical periodontal therapy * No pregnancy or lactation Exclusion Criteria: * Presence of systemic diseases that may affect wound healing * Current orthodontic treatment * Smoking or alcohol use * Use of medications affecting periodontal tissues within the last two months * Inability to maintain adequate oral hygiene

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Conditions

The condition(s) this trial relates to.

Gingival Hyperplasia gingival overgrowth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic inflammatory gingival enlargement Gingival enlargement Gingival hyperplasia

Contacts and locations

Locations

  • Ataturk University Faculty of Dentistry, Department of Periodontology

    Erzurum, Turkey (Türkiye)

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