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New surgical trick may save your gums while straightening teeth

NCT ID NCT05264480

Prevention Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bone graft to support the teeth during movement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2019

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * tooth crowding exceeding a 5mm lack of space (originating from the discrepancy between the overall mesiodostal length of the teeth and the length of the dental arch present at the time of the evaluation) * thin bone morphotype (buccal width of the cortical layer must be under 1mm) * incisor proclination in order to eliminate crowding without compensatory extractions. * informed consent Exclusion Criteria: * ongoing periodontitis * Pregnant women. * Participation in another clinical study within 30 days prior to study start. * Alcoholism, drug dependency, heavy smoking (\>5 cigarettes/day). * Known infection with HIV, HBV, or HCV. * Patients requiring chemo- or radiotherapy. * Previous or current radiotherapy of the head. * Uncontrolled or insulin-dependent diabetes mellitus * Clinically relevant osteoporosis or systemic disease affecting bone metabolism * Clinically relevant cardiovascular disease e.g., decompensated cardiac insufficiency, hemodynamically relevant heart valve defects, or myocardial infarction during the last three months. * Clinically relevant blood coagulation disorder. * Previous or current treatment with systemic corticosteroids (within 2 months prior to screening visit) of more than 5 mg/day prednisone equivalent. * Previous or current therapy with bisphosphonates at least for 30 days within the last 12 months before screening visit

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Conditions

The condition(s) this trial relates to.

Bone Diseases, Metabolic osteoporosis gingival recession prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone loss Tooth movement

Contacts and locations

Locations

  • Semmelweis University Department of Periodontology

    Budapest, Budapest, 1088, Hungary

More trials for these conditions

Other studies related to the condition(s) this trial covers.