Can a simple mouthwash tame the painful side effects of radiation?
NCT ID NCT07748442
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests two different mouthwashes—benzydamine hydrochloride and super saturated calcium phosphate—to see which better prevents and manages oral mucositis, a painful inflammation of the mouth lining, in head and neck cancer patients receiving radiation therapy. Participants will use one of the mouthwashes during their treatment, and researchers will track the severity of mouth sores weekly. The study also measures a protein in saliva to see if it can predict how severe the mucositis becomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Benzydamine hydrochloride mouthrinse and super saturated calcium phosphate oral rinse
- What this could lead to
- If successful, this could identify a better mouthwash to reduce the severity of painful mouth sores during radiation therapy, improving quality of life for head and neck cancer patients.
- What could go wrong
- This is a small early-stage trial, so results may not be conclusive. The effectiveness may vary among individuals, and there is a risk of side effects from the mouthwashes themselves.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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42 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Apr 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients of either gender (age group 30-70 years) with any histological type of head and neck cancers having a treatment plan to receive radiotherapy. Exclusion Criteria: * Patients with poorly controlled diabetes mellitus * Patients with prior xerostomia * Patients with a history of chemo/radiotherapy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Post Graduate Medical Institute, Lahore.
Lahore, Punjab Province, 54000, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Experimental pill HG146 put to the test against rare head and neck cancer
- Can a dental assistant keep cancer Patients' mouths healthier during radiation?
- Why do Non-Smokers get head and neck cancer? scientists probe tumor DNA
- Re-irradiation plus cetuximab targets head and neck tumors that return
- Sharper tumor maps: PET scans could tighten radiation beams
- Five days of radiation instead of weeks: a new test for head and neck cancer