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Tooth blood test could tell if a root canal is really needed

NCT ID NCT07658742

Diagnosis Sponsor: Safa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of pulp blood during routine dental treatment from 75 healthy people aged 12–35. They will measure levels of various inflammatory and other biomarkers and compare them across healthy teeth, reversible pulpitis, and irreversible pulpitis. The goal is to find biomarkers that improve diagnostic accuracy and guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more accurate diagnostic test for pulpitis, helping dentists decide when a root canal is truly needed.
What could go wrong
This is an observational study with a small sample size (75 teeth). The biomarkers may not prove reliable enough for routine clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

90 people

The number who actually took part.

Started

Nov 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 12-35 years who presented to the Department of Endodontics or Pediatric Dentistry for routine restorative or root canal treatment and met the study eligibility criteria. Participants were classified into three groups according to pulpal diagnosis: normal pulp, reversible pulpitis, and irreversible pulpitis. Only systemically healthy individuals with vital teeth and sufficient pulpal blood sample collection during routine treatment procedures were included.

Ages

12 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 12 to 35 years * Systemically healthy individuals * Patients presenting for routine restorative treatment or root canal treatment * Teeth classified into one of the following pulpal status groups: healthy pulp, reversible pulpitis, or irreversible pulpitis * Confirmation of pulp vitality by pulp sensibility tests * Ability to obtain pulp exposure and collect an adequate pulpal blood sample during treatment Exclusion Criteria: * No response to pulp sensibility tests * Teeth that are not restorable * Presence of a sinus tract * Radiographic evidence of periapical pathology * Presence of internal or external root resorption * Teeth with open apices * Presence of systemic disease * Pregnancy * History of non-steroidal anti-inflammatory drug (NSAID) or antibiotic use within the last week * Requirement for prophylactic antibiotic use * Teeth in which pulp exposure cannot be achieved after complete caries removal

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy pulp Irreversible pulpitis Reversible pulpitis

Contacts and locations

Locations

  • Kütahya Health Sciences University Faculty of Dentistry

    Kütahya, Kütahya, 43100, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.