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Chilling dental anesthetic may cut root canal pain

NCT ID NCT06194721

Symptom relief Sponsor: Gulf Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either cold or room temperature, and researchers compare pain levels reported during the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cooled local anesthetic injected into the tooth's pulp
What this could lead to
If cooling the anesthetic helps, dentists could use this simple step to make root canal treatment less painful for patients with inflamed tooth nerves.
What could go wrong
This is a small study of 40 people at one dental school. The cooling step may not make a noticeable difference, and results might not apply to other teeth or clinics.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jun 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with mandibular molars diagnosed with symptomatic irreversible pulpitis. * Mandibular molars with closed apices. * Patients who are experiencing pain during access cavity drilling above 5 visual analog scale. Exclusion Criteria: * • Patients with a known allergy to lidocaine. * Root canal-treated mandibular molars. * Patients with systemic diseases. * Mandibular molars with open apices. * Mandibular molars with external/internal resorption. * Non-restorable mandibular molars.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis

Contacts and locations

Locations

  • Gulf Medical University

    Ajman, Ajman Emirate, 4184, United Arab Emirates

More trials for these conditions

Other studies related to the condition(s) this trial covers.