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Sweet relief? candy and honey may shield salivary glands from radiation damage

NCT ID NCT01833650

Symptom relief Sponsor: Cyprus University of Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether sucking lemon candy and using honey mouthwash can reduce salivary gland damage caused by radioiodine therapy for thyroid cancer. About 120 adults who have had their thyroid removed and are about to receive radioiodine will be randomly assigned to the candy-and-honey routine or standard care. The goal is to see if these simple, everyday products can lower the risk of painful gland inflammation and dry mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lemon candy and thymus honey mouthwash
What this could lead to
If it works, this simple, low-cost approach could help prevent dry mouth and salivary gland damage in people undergoing radioiodine therapy for thyroid cancer.
What could go wrong
This is a small, early-stage trial. The benefit may be modest, and honey is not suitable for people with diabetes or honey allergies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Feb 2018

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>18 years old * They had a histological diagnosis of papillary, follicular, medullary or anaplastic thyroid cancer * They had undergone total thyroidectomy * They were able to provide consent Exclusion Criteria: * patients who had distant metastases, * a history of salivary-gland disorders, * collagen tissue disease * diabetes mellitus, * previous radioiodine therapy or external radiation to the head or neck * allergy to the honey

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Conditions

The condition(s) this trial relates to.

sialadenitis thyroid cancer Thyroid Neoplasms Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thyroid cancer

Contacts and locations

Locations

  • Bank of Cyprus Oncology

    Nicosia, Nicosia, 2006, Cyprus

More trials for these conditions

Other studies related to the condition(s) this trial covers.