Could a saliva test spot gum and implant disease early?
NCT ID NCT07187323
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to find a simple, non-invasive way to diagnose and monitor gum and implant disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple saliva test to help dentists tell apart different types of gum and implant disease.
- What could go wrong
- This is a small, completed observational study. The findings may not apply to everyone, and more research is needed before any test becomes available.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
120 people
The number who actually took part.
- Started
-
Aug 2024
- Finished
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Aug 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The patients who has healthy implants, the peri implant mucositis patients, peri-implantitis patients, periodontally healthy volunteers, gingivitis and stage 3 grade b patients were enrolled in this study.
- Ages
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20 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * be between 18 and 65 years of age * have a minimum of 20 natural teeth, excluding third molars (for non-implant-treated groups) * be edentulous patients treated with implants loaded at least 1 year prior (for implant-treated groups) * be in a systemically healthy condition. Exclusion Criteria: * current tobacco use * chronic use of any systemic medication * use of antibiotics, anti-inflammatory drugs (including corticosteroids and NSAIDs), immunosuppressants, beta-blockers, calcium channel blockers, anticoagulants, or hormonal contraceptives within the 3 months prior to the study * receipt of periodontal therapy within the past 6 months * pregnancy or breastfeeding * presence of orthodontic appliances a DMFT index (Decayed, Missing, and Filled Teeth per tooth) greater than 2
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istanbul Medipol University, School of Dentistry
Istanbul, Istanbul, 34083, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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