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Which membrane best preserves bone after tooth extraction? study seeks answer.

NCT ID NCT05505084

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared five different membranes used to preserve the jawbone after a tooth is pulled. Bone loss after extraction is common, and membranes help protect the area for future dental implants. Researchers measured bone changes and tissue quality in 47 adults who needed a premolar removed. The goal was to see which membrane works best, but no clear winner has been identified yet.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify the best membrane for preserving jawbone after tooth extraction, improving outcomes for dental implants.
What could go wrong
This is a small, completed study with only 47 participants, so results may not apply to everyone. It compares existing methods, so no new treatment is being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

47 people

The number who actually took part.

Started

Aug 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of subjects presenting to the University of Pennsylvania School of Dental Medicine who require extraction of a hopeless tooth due to trauma, caries, or endodontic/periodontal reasons, and who are interested in replacing their tooth with a dental implant.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects must between the ages of 18 and 80. * Subjects must require removal of at least one maxillary premolar * Subjects should benefit from an implant-supported crown. * Subjects must have voluntarily signed the informed consent form. * Subjects must be assessed as ASA I, ASA II by a member of the research team. Exclusion Criteria: * Medical conditions requiring the use of steroids. * History of leukocyte dysfunction or deficiencies, bleeding deficiencies, renal failure, uncontrolled endocrine disorders, acquired immunodeficiency syndrome or hepatitis. * History of neoplastic disease requiring the use of chemotherapy or irradiation to head and neck. * Subjects who have diabetes mellitus. * Subjects who have undergone administration of any investigational drug or device within 30 days of enrollment in the study. * Alcohol or drug abuse. * Subjects who are heavy smokers (greater than 10 cigarettes per day or cigar equivalents) or chew tobacco. * Conditions or circumstances, in the opinion of the research team, which would prevent completion of study participation or interfere with analysis of study results, such as a history of non-compliance or unreliability.

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Conditions

The condition(s) this trial relates to.

dental caries Tooth Fractures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries Tooth extraction status nos Tooth fractures

Contacts and locations

Locations

  • Penn Dental Medicine

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.