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Can a blood gel with antibiotics speed wisdom tooth healing?

NCT ID NCT07764757

Disease control Sponsor: Amerigo Giudice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This trial tests whether adding an antibiotic to a blood-derived gel (platelet-rich fibrin) placed in the socket after wisdom tooth removal improves recovery. It compares the antibiotic-enriched gel to a standard gel in the same person, measuring swelling, pain, and infection risk. Participants are healthy adults aged 18-34 with both lower wisdom teeth needing removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Antibiotic-enriched platelet-rich fibrin (PRF), a blood-derived gel with added antibiotic, placed in the tooth socket after extraction.
What this could lead to
If effective, this approach could reduce pain, swelling, and infection risk after wisdom tooth surgery, potentially speeding recovery and reducing the need for oral antibiotics.
What could go wrong
This is a small early-stage trial, so results may not apply broadly. Risks include possible allergic reactions to the antibiotic or the procedure itself, and the added benefit over standard PRF may be minimal.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Nov 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 32 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy patients (ASA I) according to the American Society of Anesthesiologists classification. * Age 18-32 years. * Ability to provide written informed consent. * Bilateral mandibular third molars requiring extraction for prophylactic, therapeutic, or strategic reasons. * Complete root development of mandibular third molars (Shumaker Stage H). * Availability of diagnostic-quality CBCT scans with adequate field of view (17 × 20). * Mandibular third molars classified as having conventional or moderate surgical difficulty according to Juodzbalys and Daugela classification. Exclusion Criteria: * Known allergy to corticosteroids. * Immunosuppression or immunocompromised conditions. * Acute infection at the mandibular third molar extraction sites. * Current or previous intravenous amino-bisphosphonate therapy. * Psychiatric disorders. * Thrombocytopenia (platelet count \<40,000/µL), thrombocytosis, or other coagulation disorders. * Severe hepatic cirrhosis, advanced chronic renal failure, or uncontrolled -diabetes mellitus. * Pregnancy or breastfeeding. * Requirement for additional regenerative procedures (e.g., bone grafting). * Localized facial malformations involving the cheek region.

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Conditions

The condition(s) this trial relates to.

impacted teeth, multiple Tooth Avulsion Tooth, Impacted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial swelling Tooth avulsion Tooth extraction status nos Tooth position anomalies Tooth, impacted

Contacts and locations

Locations

  • Magna Graecia University of Catanzaro

    Catanzaro, cz, 88100, Italy

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