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Root canal pain relief may depend on your DNA

NCT ID NCT07012382

Knowledge-focused Sponsor: Jamia Millia Islamia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek swabs, they aimed to see if certain gene types are linked to poor numbing. The goal is to understand why some people don't get numb and potentially personalize dental pain management.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict who might not get numb from standard injections, leading to personalized anesthetic plans for root canal patients.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings may not apply to all patients or change clinical practice directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

320 people

The number who actually took part.

Started

May 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-50 years. * Requiring root canal treatment in mandibular first or second molars diagnosed with irreversible pulpitis. * Administration of standard IANB with 2% lidocaine containing 1:80,000 epinephrine. * Ability to provide informed consent. Exclusion Criteria: * Systemic conditions affecting pain perception (e.g., diabetes, neuropathies). * Known allergy to local anesthetics. * Use of analgesics or anti-inflammatory medications within 24 hours before the procedure. * Pregnant or lactating women. * Patients with extensive periapical pathology or swelling. * Inability to comply with study requirements.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis - irreversible

Contacts and locations

Locations

  • Faculty of Dentistry, Jamia Millia Islamia

    New Delhi, New Delhi, 110025, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.