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Alcohol may weaken dental anesthesia, new study suggests

NCT ID NCT06201871

Knowledge-focused Sponsor: Jamia Millia Islamia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain during treatment. The goal is to understand if drinking habits influence how well dental anesthesia works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine Hydrochloride
What this could lead to
If successful, this could help dentists tailor anesthesia approaches for patients who drink alcohol, potentially improving pain control during dental procedures.
What could go wrong
This is a small, completed study with only 70 participants, so results may not apply broadly. It does not test a new treatment, only observes differences in anesthesia success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

236 people

The number who actually took part.

Started

Jan 2024

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Symptomatic carious exposed mandibular first or second molars. * Alcoholic patients: Patient with low-moderate drinking levels according to the US National Institute on Alcohol Abuse and Alcoholism * Control patients: No history of alcohol consumption * Positive and prolonged response to thermal sensitivity tests and electric pulp test. * Vital coronal pulp on access cavity preparation. * American Society of Anesthesiologists class I or II medical history. * Ability to understand the use of pain scales. Exclusion Criteria: * Active pain in more than 1 teeth * Teeth with fused roots. * Radiographic evidence of an extra root. * Large restorations with overhanging margins. * Full crowns or deep periodontal pockets. * Hypertension or cardiovascular diseases, compromised immunity, active infection or inflammation * Known allergy or contraindications to any content of the local anesthetic solution or non-steroidal anti-inflammatory drugs (NSAIDs) * History of known or suspected drug abuse. * Taking any drugs which could affect the pain perception, e.g, opioids, antidepressants, anticonvulsants, muscle relaxants, anxiolytics, sedatives, nsaids. 23 * Pregnant or breastfeeding patients. * Patients with asthma, gastric ulcers, bleeding disorders.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis - irreversible

Contacts and locations

Locations

  • Faculty of Dentistry, Jamia MIliia Islamia

    New Delhi, New Delhi, 110025, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.