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New dental cement could save Kids' teeth without root canals

NCT ID NCT07522723

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three special dental cements—Bio C Repair, Biodentine, and MTA—as treatments for irreversible pulpitis (nerve infection) in children's permanent molars. Sixty kids aged 6-10 will receive one of the materials after removing the infected pulp. The goal is to see which material best helps the tooth root finish growing and keeps the tooth healthy and pain-free.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dental materials (Bio C Repair, Biodentine, Mineral Trioxide Aggregate)
What this could lead to
If successful, this could provide dentists with a reliable, less invasive treatment to save infected young permanent teeth and avoid extraction.
What could go wrong
This is a small, early-stage trial with only 60 participants, and results may not apply to all cases. The materials may fail to control infection or promote root closure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 10 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Children aged 6-10 years with asymptomatic/symptomatic disease and having vital immature permanent posterior teeth with clinical exposure to dental caries of the pulp and bleeding. 2. Posterior teeth had deep caries with pulp exposure. 3. Posterior teeth that exhibited preoperative symptoms, such as referred pain, spontaneous pain or pain induced during thermal and cold sensitivity tests, with a range of symptoms that can last from seconds to hours compared to the control teeth. 4. Posterior teeth without prominent radiolucency in the furcation or periapical regions. 5. The posterior teeth could be restored. 6. Children with prior parental consent. Exclusion Criteria: * • (1) Patients with contraindications of the to-be-performed dental treatment. * (2) Teeth with completed VPT or RCT. * (3) Teeth with furcation, prominent radiolucency in the periapical regions, or external or internal resorption. * (4) Teeth with pulpitis attributed to tooth fracture, cracking, periodontitis or wedge-shaped defects. * (5) Teeth without any response to experiments of vitality. ( * 6\) Teeth with formed root/closed apex. * (7) Teeth with edema, fistula and excessive mobility not associated with periodontal disease.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis - irreversible

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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