Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Why your dental numbing shot might not work: gene and inflammation clues

NCT ID NCT07532200

Knowledge-focused Sponsor: Jamia Millia Islamia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success. About 100 adults with infected lower molars will participate. The goal is to understand biological factors behind failed dental numbing, which could eventually lead to better pain control strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict which patients might need extra anesthesia for painful tooth infections, improving pain management.
What could go wrong
This is a small observational study, not a treatment trial. It only looks for links between genes, inflammation, and anesthesia success—it won't directly improve care yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients presenting to the postgraduate endodontic clinic with symptomatic irreversible pulpitis in mandibular first or second molars requiring root canal treatment. Eligible participants will be systemically healthy (ASA I or II), aged between 18 and 60 years, and will report moderate to severe preoperative pain. Diagnosis will be established based on clinical findings, including spontaneous pain, prolonged response to cold testing, and absence of periapical pathology requiring surgical intervention.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-60 years * Systemically healthy individuals (ASA I or II) * Presence of a mandibular first or second molar diagnosed with symptomatic irreversible pulpitis * Vital tooth confirmed by positive response to pulp sensibility tests (cold test/EPT) * Moderate to severe preoperative pain (Heft-Parker VAS) * Patients requiring endodontic treatment under inferior alveolar nerve block * Ability and willingness to provide informed consent Exclusion Criteria: * Patients who have taken analgesics, anti-inflammatory drugs, or antibiotics within the last 48 hours * Presence of systemic diseases affecting pain perception or inflammation (e.g., diabetes, neuropathic disorders) * Pregnant or lactating women * Teeth with periapical abscess, swelling, or sinus tract * Non-vital teeth or teeth with previous endodontic treatment * Patients with known allergy to local anesthetic agents * Patients with limited mouth opening or anatomical conditions affecting IANB administration * Inability to understand pain assessment scales or comply with study protocol

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Pulpitis - irreversible are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis - irreversible

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110025, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.