Vitamin d may soothe root canal pain, small trial hints

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with serum 25-hydroxyvitamin D level below 30 nmol/L with no vitamin D supplementation for the preceding 3 months. * Patients diagnosed with symptomatic irreversible pulpitis. * Mandibular first molar: Classification of root canal configuration according to Weine's classification: * Distal root: with one portal of exit * Mesial root: Type III, two separate and distinct canals extend from the pulp chamber to the apex. * Patients with moderate to severe pre-operative pain with pain score from 6-10. * Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). * The age range is between 20 to 45 years. * Patients have restorable mandibular permanent molars that were diagnosed with symptomatic irreversible pulpitis. * Positive patient's acceptance for participating in the study and signing informed consent Exclusion Criteria: * Patients that have been taking vitamin D supplements in the last 3 months. * Patients with serum 25-hydroxyvitamin D level above 30 nmol/L. * Patients diagnosed with necrosis, partial necrosis, acute or chronic abscess. * Presence of periapical radiolucency. * Patients with systemic conditions that may affect pain perception (e.g., fibromyalgia, diabetes, chronic pain disorders). * Pregnant or lactating females. * Psychologically disturbed patients. * Patients with a history of allergy to any medication used in the study are excluded. * Patients with mild to moderate pain with pain scores less than 6. * Teeth that have: * Periodontally affected molars with grade 2 or 3 mobility. * Non-restorable teeth. * Abnormal anatomy and calcified canals. * Previous root canal treatment. * Patients above 45 years old or below 20 years old. * Non-compliant patients to follow ups. * Patients with very poor oral hygiene.