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Natural remedy st. John's wort put to the test against standard mouth ulcer treatments

NCT ID NCT06839313

Symptom relief Sponsor: Batman University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study compares three treatments for recurrent aphthous stomatitis (canker sores): St. John's wort oil, a topical corticosteroid, and hyaluronic acid gel. Researchers measure how well each reduces pain, shrinks ulcer size, and speeds healing in adults with a history of these painful mouth ulcers. The goal is to find which option works best for symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
St. John's wort oil, topical corticosteroids, hyaluronic acid
What this could lead to
If successful, this could identify a more effective or natural option for easing pain and speeding healing of recurrent mouth ulcers.
What could go wrong
This is a small, early-stage study (75 people) comparing existing treatments, so results may not be definitive or widely applicable. Individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18 years and over 2. Having a history of RAS for at least 2 years 3. Having one in an easily accessible area in the mouth 4. RAS has not exceeded a period of 48 hours Exclusion Criteria: 1. Having any allergic history to these substances to be applied 2. During pregnancy and lactation 3. Use of steroids, vitamins, antibiotics, antihistamines, oral retinoids or immune system regulating agents for ulcer treatment within 3 months 4. The patient has a history of systemic disease

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Conditions

The condition(s) this trial relates to.

aphthous stomatitis canker sore Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stomatitis, aphthous

Contacts and locations

Locations

  • Batman University

    Batman, Centre/Batman, 72100, Turkey (Türkiye)