Aphthous stomatitis
MONDO:0004845A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval, lasting for 7-14 days and healing without scarring.
Also known as: oral aphthae, canker sore
12 clinical trials for this condition and its sub-types, 12 tagged with Aphthous stomatitis itself.
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Blue-Green algae vs. painful mouth sores: a trial puts spirulina to the test
Disease control Recruiting nowThis trial tests whether spirulina, a dietary supplement made from blue-green algae, can reduce the severity and pain of recurrent aphthous ulcers (canker sores). Forty adults with active mouth ulcers will receive either spirulina tablets or a placebo for a set period. Researcher…
Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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New drug aims to silence painful mouth ulcers
Disease control Recruiting nowThis Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, fol…
Phase 3 • Sponsor: University Hospital, Rouen • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Could a special gel make canker sores disappear faster?
Symptom relief Recruiting nowThis study tests whether an oxygenated gel can reduce pain and speed up healing of canker sores (aphthous ulcers) compared to a standard steroid gel. Thirty adults with a single small ulcer will apply the gel twice daily for 7 days. Researchers will check pain levels and ulcer si…
Phase 2/3 • Sponsor: British University In Egypt • Aim: Symptom relief
Last updated Jun 26, 2026 18:18 UTC