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Ozone treatment eases mouth pain for head and neck cancer patients

NCT ID NCT07199712

Symptom relief Sponsor: University of Pavia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days. The main goal was to see how quickly sores healed and pain decreased. The research aims to find a simple supportive care option to improve comfort and keep cancer treatment on track.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy (professional ozone gas treatment and home ozonated toothpaste, mouthrinse, and gel)
What this could lead to
If it works, this could offer a simple, drug-free way to reduce mouth sore pain and speed healing during cancer treatment, improving quality of life.
What could go wrong
This is a small, completed trial with no control group, so results may not be definitive. Ozone therapy is generally safe but may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

58 people

The number who actually took part.

Started

Oct 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years. * Currently undergoing oncologic therapy (radiotherapy, chemotherapy, or combined treatment). * Presence of oral mucositis or stomatitis of at least WHO grade 1 at baseline evaluation. Exclusion Criteria: * Pregnant women. * Patients with Down syndrome. * Patients with epilepsy. * Patients with cardiac pacemakers. * Patients with marked sensitivity to electrical current. * Non-cooperative patients.

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Conditions

The condition(s) this trial relates to.

agnosia chemotherapy-induced oral mucositis Head and Neck Neoplasms head and neck squamous cell carcinoma mucositis stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chemotherapy induced mucositis Head and neck cancer squamous cell carcinoma Oral mucositis Oral stomatitis Radiotherapy induced mucositis

Contacts and locations

Locations

  • Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia

    Pavia, Lombardy, 27100, Italy

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