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Toothpaste showdown: could stannous fluoride outperform potassium for sensitive teeth?

NCT ID NCT07738198

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial compares a toothpaste with stannous fluoride against a popular potassium-based desensitizing toothpaste and a regular fluoride toothpaste. About 116 adults with sensitive teeth will brush twice daily for a week. The goal is to see if the stannous fluoride formula reduces sensitivity to touch and air blasts better than the others.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stannous fluoride toothpaste
What this could lead to
If effective, this toothpaste could offer a more reliable option for people with sensitive teeth, reducing discomfort from hot, cold, or air triggers.
What could go wrong
The trial is relatively small and short-term, so results may not apply to everyone. Also, individual responses to toothpaste can vary, and the effect may not last beyond the study period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

116 people

The number who actually took part.

Started

Nov 2018

Finished

Dec 2018

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Must be male or female 18 to 70 years of age * Must give written informed consent * Must be in good general health as determined by the study investigators * Must be available for the seven day duration of the study * Must have 2 hypersensitive teeth which must meet ALL of the following inclusion criteria: Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion or gingival recession. Have a qualifying dentin hypersensitivity response to tactile stimuli applied to the cervical surface (gingivo-facial 1/3) as defined by a response score between 10-50grams of force (Yeaple Probe, XiniX Research Inc. Portsmouth, NH, USA). -Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale Exclusion Criteria: * Allergies to oral care products, personal care consumer products, or their ingredients. * Use of a desensitizing oral care product or recipient of desensitizing treatment within three months prior to start of the study. * Gross oral pathology, advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months. * Sensitive teeth with a mobility greater than one. * Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures. * Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics * Participation in any other oral clinical studies for the duration of this study * Full or partial removable oral prostheses * Pregnant or lactating (breast feeding) * Allergies to oral care products, personal care consumer products, or their ingredients. * Medical condition which prohibits not eating/drinking for 4 hours

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • FAR Oral and Systemic Health Consulting, Inc

    Costa Mesa, California, 92627, United States

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Other studies related to the condition(s) this trial covers.