Toothpaste showdown: could stannous fluoride outperform potassium for sensitive teeth?
NCT ID NCT07738198
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial compares a toothpaste with stannous fluoride against a popular potassium-based desensitizing toothpaste and a regular fluoride toothpaste. About 116 adults with sensitive teeth will brush twice daily for a week. The goal is to see if the stannous fluoride formula reduces sensitivity to touch and air blasts better than the others.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stannous fluoride toothpaste
- What this could lead to
- If effective, this toothpaste could offer a more reliable option for people with sensitive teeth, reducing discomfort from hot, cold, or air triggers.
- What could go wrong
- The trial is relatively small and short-term, so results may not apply to everyone. Also, individual responses to toothpaste can vary, and the effect may not last beyond the study period.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
116 people
The number who actually took part.
- Started
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Nov 2018
- Finished
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Dec 2018
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Must be male or female 18 to 70 years of age * Must give written informed consent * Must be in good general health as determined by the study investigators * Must be available for the seven day duration of the study * Must have 2 hypersensitive teeth which must meet ALL of the following inclusion criteria: Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion or gingival recession. Have a qualifying dentin hypersensitivity response to tactile stimuli applied to the cervical surface (gingivo-facial 1/3) as defined by a response score between 10-50grams of force (Yeaple Probe, XiniX Research Inc. Portsmouth, NH, USA). -Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale Exclusion Criteria: * Allergies to oral care products, personal care consumer products, or their ingredients. * Use of a desensitizing oral care product or recipient of desensitizing treatment within three months prior to start of the study. * Gross oral pathology, advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months. * Sensitive teeth with a mobility greater than one. * Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures. * Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics * Participation in any other oral clinical studies for the duration of this study * Full or partial removable oral prostheses * Pregnant or lactating (breast feeding) * Allergies to oral care products, personal care consumer products, or their ingredients. * Medical condition which prohibits not eating/drinking for 4 hours
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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FAR Oral and Systemic Health Consulting, Inc
Costa Mesa, California, 92627, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.