Skip a day, save your smile: new whitening trick cuts sensitivity
NCT ID NCT06035588
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether using a 16% carbamide peroxide whitening gel every other day causes less tooth sensitivity than using it every day. 110 adults with healthy teeth applied the gel for two hours over three weeks. The goal was to see if alternating days reduces pain while still whitening teeth effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 16% carbamide peroxide bleaching gel
- What this could lead to
- If successful, this could offer a way to whiten teeth with less pain, making the process more comfortable for patients.
- What could go wrong
- This is a small, completed study with 110 participants, so results may not apply to everyone. The gel still causes some sensitivity, and whitening might be less effective with alternate-day use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
110 people
The number who actually took part.
- Started
-
Jan 2024
- Finished
-
Sep 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients older than 18 years. * Patients with vital teeth without restorations, single crowns, implants and/or bridges at the level of the anterior teeth. * Absence of cavities in the teeth to be whitened. * Patients with satisfactory oral hygiene and periodontally healthy, who are not undergoing periodontal maintenance and who do not use chlorhexidine mouthwashes. Patients with recessions without presenting sensitivity will be included. * Absence of sensitivity, measured with the application of air with the dental team's syringe. * Patients whose canines have at least an A2-A3 shade (VITA Classic® Guide). Exclusion Criteria: * Patients who have previously undergone whitening (less than 5 years). * Patients undergoing orthodontic treatment. * Patients with white spots or alterations in the development of enamel or with stains. * Patients with a history of trauma to anterior teeth. * Patients who require internal whitening. * Smokers. * Pregnant or lactating. * Patients with allergies to any whitening component. * Patients presenting alterations of the oral mucosa (desquamative gingivitis, oral lichen planus, leukoplakia, etc.). * Patients with medical conditions considered by the researchers that may compromise the study or the individual safety of the patient. * Patients with poor oral hygiene. * Patients with previous hypersensitivity.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Dental hypersensitivity are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Isabel Giraldez de Luis
Alcorcón, Madrid, 28922, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.