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Can dead teeth be brought back to life? new study tests regeneration vs. standard cleaning

NCT ID NCT07609732

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing and any return of tooth sensation. The goal was to see which method best resolves infection and potentially restores tooth vitality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Regenerative endodontic procedure (bleeding induction) and standard cleaning and shaping
What this could lead to
If successful, this could offer a way to restore vitality in dead adult teeth, potentially avoiding root canals or extractions.
What could go wrong
This is a small, completed trial with only 54 participants, so results may not apply broadly. Regeneration may not reliably restore nerve function or long-term tooth health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

54 people

The number who actually took part.

Started

Aug 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 20-50 years * Medically free * The patient should have the upper first premolar that needs endodontic treatment with apical periodontitis * Necrotic teeth * Participants were willing to commit to the entire period of the trial and agreed to sign the written consent after a full explanation of the study. Exclusion Criteria: * Symptomatic irreversible pulpitis * If the premolar is non restorable * If the premolar will need a post and core * Vertical root fracture * Open apex * Presence of any systemic disease or allergic reactions. * Vulnerable group; prisoners, pregnant females, mentally ill, etc…

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cleaning and shaping only with proper coronal seal Necrotic mature first premolar Regenerative endodontic treatment

Contacts and locations

Locations

  • Faculty Of Dentistry Ain Shams University

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

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