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Can a gentler root canal save more tooth and still heal infection?

NCT ID NCT07762248

Disease control Sponsor: Mohamed Ashraf Abdeen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conservative or a standard root canal treatment. Over 12 months, the study will compare how well each method clears infection and promotes bone healing around the tooth root.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Root canal treatment (minimally invasive vs traditional procedure)
What this could lead to
If minimally invasive root canal treatment works as well as the traditional approach, it could preserve more natural tooth structure and improve recovery for people with infected molars.
What could go wrong
This is a relatively small trial, and the minimally invasive approach may not disinfect the root canals as effectively, potentially leading to a higher risk of persistent infection or treatment failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants with free medical history (category: American Society of Anaesthesiologists class I) from either gender aged from 20 to 50 years old. 2. Necrotic lower first molars with four root canals (two mesials and two distals). 3. Teeth have a periapical radiolucency with a diameter of 2-4 mm in CBCT images. 4. Teeth show root curvature of 10°-20° as described by Schnider. 5. Participant that indicated for single visit root canal treatment. Exclusion Criteria: 1. Calcified or non-negotiatable teeth. 2. Participants who cannot apply for the follow-up schedule. 3. Teeth that show any signs of cracks or vertical root fractures. 4. Teeth that show less than 50% of sound coronal tooth structure. 5. Periodontally affected teeth.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Necrotic mandibular molars

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of dentistry, Assiut university

    Asyut, Asyut Governorate, Egypt

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