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Can a simple mouthwash silence sensitive teeth?

NCT ID NCT07741032

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether two experimental mouthwashes can relieve dentinal hypersensitivity—sharp pain from hot, cold, or air on teeth. About 118 adults with sensitive teeth will use one of the mouthwashes or a placebo, either once or twice daily, for up to 8 weeks. Researchers will measure changes in sensitivity to air and touch, as well as how the condition affects quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two experimental mouthwashes: one with 3% potassium nitrate (KNO3) and one with 2% hydroxypropyl cellulose (HPC), both with fluoride, compared to a placebo mouthwash.
What this could lead to
If successful, these mouthwashes could offer a simple, at-home way to reduce tooth sensitivity and improve comfort when eating, drinking, or brushing.
What could go wrong
This is an early proof-of-concept study, so results may not hold up in larger trials. The mouthwashes might not outperform the placebo, and some people may not respond to treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

118 people

The number who actually took part.

Started

Mar 2012

Finished

Jul 2012

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant who demonstrates understanding of the study and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form. * Participant understands and is willing, able and likely to comply with all study procedures and restrictions. * A participant with a minimum of 20 natural teeth and in good general health who suffer from tooth sensitivity. * At screening, participants with a minimum of four accessible nonadjacent teeth (incisors, canines, or pre-molars) with signs of facial/cervical gingival recession and/or signs of erosion or abrasion. * At screening, self-reported history of Dentinal Hypersensitivity lasting more than 6 months but not more than 10 years. * At Baseline: Minimum of two, non-adjacent accessible teeth (incisors, canines, premolars), that meet all of the following criteria: - Tooth with signs of sensitivity, measured by qualifying tactile stimulus (Yeaple less than or equal to \[\<=\] 20 gram) and evaporative (air) assessment (Schiff Sensitivity Score greater than or equal to \[\>=\] 2) Exclusion Criteria: * Women who are known to be pregnant or who are intending to become pregnant over the duration of the study. * Women who are breastfeeding. * Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients. * Participation in another clinical study or receipt of an investigational drug within 30 days of the Screening visit. * Participation in a desensitising treatment study within 8 weeks of the Screening visit. * Previous participation in this study. * Recent history (within the last year) of alcohol or other substance abuse. * An employee of the sponsor or the study site or members of their immediate family. * Presence of chronic debilitating disease which, in the opinion of the investigator, could affect study outcomes. * Dental prophylaxis within 4 weeks of Screening. * Tongue or lip piercing or presence of dental implants. * Desensitizing treatment within 8 weeks of Screening. * Teeth bleaching within 8 weeks of Screening. * Any participant who, in the judgment of the investigator, should not participate in the study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • proDERM

    Harburg, Free and Hanseatic City of Hamburg, Germany

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