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New toothpaste fights gum disease in 12-Week trial

NCT ID NCT07640399

Disease control Sponsor: Church & Dwight Company, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to see if the special toothpaste leads to healthier gums.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stannous fluoride toothpaste
What this could lead to
If it works, this toothpaste could offer a better option for managing gum inflammation and bleeding at home.
What could go wrong
This is a small, completed trial with no phase designation, so results may not apply to everyone. Toothpaste effects are modest and not a substitute for professional dental care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

133 people

The number who actually took part.

Started

Mar 2025

Finished

Jun 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects aged 18 to 65 years (inclusive) * Provided written informed consent prior to participation * Able to brush their own teeth on a daily basis * In good general health based on medical history review * Minimum of at least 18 natural, scorable teeth * Mean plaque index score ≥ 1.95 * Mean baseline gingival index score ≥ 1.70 and ≤ 3.0 * Agreed to refrain from use of all oral hygiene products other than those supplied for the study * Agreed to refrain from oral hygiene, eating, drinking, and chewing gum for approximately 12 hours prior to study visits * Agreed not to undergo dental prophylaxis or elective dental procedures during the study * Willing and able to comply with study procedures and visit schedule Exclusion Criteria: * Physical limitations or restrictions that preclude normal tooth brushing * Requirement for premedication prior to dental treatment * Pregnancy or intent to become pregnant during the study period * Use of tobacco or nicotine products * Poor oral hygiene defined as \>40 bleeding sites * Presence of dental caries or calculus deposits that may interfere with plaque assessments * Major oral hard or soft tissue lesions or trauma at baseline * Presence of fixed or removable orthodontic appliances * Dental prophylaxis within 1 month prior to baseline visit * History of significant adverse events, allergy, or irritation related to oral hygiene products

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Conditions

The condition(s) this trial relates to.

gingivitis Hemorrhage hemorrhagic disease Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bleeding Gingival inflammation Plaque

Contacts and locations

Locations

  • All Sum

    Mississauga, Ontario, L5N 6J2, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.