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Scientists probe the chemistry of tooth pain and stress

NCT ID NCT07330024

Knowledge-focused Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal was to better understand the link between psychological factors and dental pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists better understand and manage dental pain by considering both biological and psychological factors.
What could go wrong
This is a small, observational study that only measures associations, not causes. Results may not apply to everyone or lead to direct treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

72 people

The number who actually took part.

Started

Nov 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult individuals aged 18 to 65 years who present to a university dental hospital and require endodontic treatment for permanent teeth. Participants include individuals with dental pain and individuals without dental pain, classified based on clinical examination and pain assessment. All participants are systemically healthy or have ASA physical status I or II and provide written informed consent prior to participation.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-65 years * ASA physical status I or II * Presence of permanent teeth requiring endodontic treatment * Ability to understand the study procedures and provide written informed consent * No use of analgesic medications within 24 hours prior to clinical assessment * No food or drink intake within 2 hours prior to saliva sampling Exclusion Criteria: * Periodontal disease (probing depth \>4 mm or bleeding on probing \>20%) * Systemic inflammatory, autoimmune, neuropathic, or chronic pain disorders * Acute infection, fever, or antibiotic use within the last 7 days * Pregnancy or lactation * Regular use of psychiatric medications (e.g., antidepressants, anxiolytics, antipsychotics, antiepileptics) * Tobacco use or alcohol consumption within the last 24 hours * Previous endodontic treatment or history of dental trauma in the study tooth * Systemic diseases that may affect neuropeptide levels (e.g., diabetes mellitus, thyroid disorders, renal or hepatic disease) * Use of medications affecting salivary flow

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression pulpitis Stress, Psychological Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Dental pain Psychological stress Pulpal inflammation Pulpitis

Contacts and locations

Locations

  • Kahramanmaraş Sutcu İmam University, Faculty of Dentistry

    Kahramanmaraş, onikişubat, 46010, Turkey (Türkiye)

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