New combo therapy shows promise for Tough-to-Treat head and neck cancer
NCT ID NCT03258554
First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times
Summary
This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The main goals were to check safety and see how long patients lived without their cancer getting worse. Results help doctors understand if durvalumab is a good alternative for these patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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196 people
The number who actually took part.
- Started
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Apr 2018
- Finished
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Sep 2025
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * PRIOR TO STEP 1 REGISTRATION INCLUSION CRITERIA * Patients must have pathologically confirmed, previously untreated, unresected squamous cell carcinoma of the larynx, hypopharynx, oropharynx, oral cavity, or carcinoma of unknown head/neck primary prior to step 1 registration; submission of hematoxylin and eosin (H\&E) stained slides and formalin-fixed and paraffin-embedded (FFPE) tissue block (or punch biopsy of FFPE block) to the biospecimen bank at University of California, San Francisco (UCSF) for central review for oropharyngeal and unknown primaries and for p16 analysis for all other non-oropharyngeal primaries is mandatory for all patients; investigators should check with their pathology department regarding release of biospecimens before approaching patients about participation in the trial; for oropharyngeal and unknown primaries, submission of H\&E and p16 stained slides (with the required block for PD-L1) to the biospecimen bank at UCSF for central review is also required prior to step 2 registration * Note: fine needle aspirates (FNA) samples are not acceptable since they do not provide enough material for PD-L1 and p16 testing; however, if a cell block derived from the FNA is available, it is allowable if there are sufficient cells present in the block for PD-L1 testing; Dr. Jordan will determine this upon receipt; for sites submitting FNA cell blocks for ALL patients they must do so within 7-10 business days from registering the patient; sites must confirm with their cytology/pathology labs to make sure they can provide the required material as the bank must be able to retain these samples for the mandatory testing * Patients must have locoregionally advanced head and neck squamous cell carcinoma (HNSCC) * For p16-positive oropharyngeal/unknown primaries, American Joint Committee on Cancer \[AJCC\] 8th edition stage III and selected stage I-II based on smoking status in pack-years * For laryngeal, hypopharyngeal, and oral cavity primaries and p16-negative oropharyngeal/unknown primaries, AJCC 8th edition stage III-IVB * Based on the following minimum diagnostic workup within 60 days prior to step 1 registration: * General history and physical examination by a radiation oncologist or medical oncologist or ear, nose and throat (ENT) or head \& neck surgeon * For larynx, hypopharynx, and base of tongue primaries, a laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) is required, unless the patient cannot tolerate or refuses * Imaging of the head and neck with a neck CT or magnetic resonance imaging (MRI) (with contrast, unless contraindicated) or PET/CT; note that the CT portion of the PET/CT must be of diagnostic quality, including contrast administration unless contraindicated. If the CT portion of the PET/CT study is low-dose (non-diagnostic), then an additional CT or MRI study with contrast (unless contraindicated) is required * Chest imaging: chest CT with and without contrast (unless contraindicated) or PET/CT * Patients must have a contraindication to cisplatin as defined in the following bullet points; sites must complete the online tool at comogram.org prior to step 1 registration to determine if the patient is eligible; the scores must be recorded on a case report form (CRF) * Age \>= 70 with moderate to severe comorbidity or vulnerability to cisplatin, defined as having one or more of the following conditions within 30 days prior to step 1 registration: * Modified Charlson Comorbidity Index \>= 1 * Adult Comorbidity Evaluation (ACE)-27 Index \>= 1 * Generalized Competing Event Model for Cancer Risk (GCE) omega PFS score \< 0.80 * Geriatric screening (G-8) score =\< 14 * Cancer and Aging Research Group (CARG) toxicity score \>= 30% * Cumulative Illness Rating scale for Geriatrics (CIRS-G) score \>= 4 OR * Age \< 70 with severe comorbidity or vulnerability to cisplatin, defined as having two or more of the following conditions within 30 days prior to step 1 registration * Modified Charlson Comorbidity Index \>= 1 * ACE-27 Index \>= 1 * GCE omega PFS-score \< 0.80 * G-8 score =\< 14 * CARG Toxicity score \>= 30% * CIRS-G score \>= 4 OR * Age \>= 18 with an absolute or relative contraindication to cisplatin, defined as one or more of the following within 30 days prior to step 1 registration: * Creatinine clearance (CC) \> 30 and \< 60 cc/min; for this calculation, use the Cockcroft-Gault formula * Zubrod performance status 2 prior to step 1 registration * Pre-existing peripheral neuropathy grade \>= 1 * History of hearing loss, defined as either: * Existing need of a hearing aid OR * \>= 25 decibel shift over 2 contiguous frequencies on a pretreatment hearing test as clinically indicated * Absolute neutrophil count (ANC) \>= 1,000 cells/mm\^3 (within 14 days prior to step 1 registration) * Platelets \>= 100,000 cells/mm\^3 (within 14 days prior to step 1 registration) * Hemoglobin \>= 9.0 g/dl (Note: the use of transfusion or other intervention to achieve hemoglobin \[Hgb\] \>= 9.0 g/dl is acceptable) (within 14 days prior to step 1 registration) * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =\< 2.5 times institutional upper limit of normal (within 14 days prior to step 1 registration) * Serum bilirubin =\< 1.5 x institutional upper limit of normal (within 14 days prior to step 1 registration) * Measured creatinine clearance (CL) \> 30 mL/min or calculated creatinine CL \> 30 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection for determination of creatinine clearance (within 14 days prior to step 1 registration) * For women of childbearing potential, a negative serum or urine pregnancy test within 14 days prior to step 1 registration; Note: women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause; the following age-specific requirements apply: * Women \< 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy) * Women \>= 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses \> 1 year ago, had chemotherapy-induced menopause with last menses \> 1 year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy) * The patient or a legally authorized representative must provide study-specific informed consent prior to step 1 registration * PRIOR TO STEP 2 REGISTRATION INCLUSION CRITERIA * For patients with oropharyngeal or unknown primaries: p16 determination by immunohistochemistry (defined as greater than 70% strong nuclear or nuclear and cytoplasmic staining of tumor cells), confirmed by central pathology review * Note: for patients with oral cavity, laryngeal, and hypopharyngeal primaries, analysis of p16 status prior to step 2 registration/randomization is not required (p16 status will be analyzed centrally post-hoc); step 2 registration for these patients can be completed after step 1 registration Exclusion Criteria: * PRIOR TO STEP 1 REGISTRATION EXCLUSION CRITERIA * Prior invasive malignancy within the past 3 years (except for non-melanomatous skin cancer, and early stage treated prostate cancer); synchronous head and neck primaries are ineligible * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields * Note: Prior external beam radiotherapy is excluded, but iodine 131 is allowed * Prior immunotherapy * Prior systemic therapy, including cytotoxic chemotherapy, biologic/targeted therapy, or immune therapy for the study cancer * Major surgery within 28 days prior to step 1 registration * Proven evidence of distant metastases * If both of the following conditions are present, the patient is ineligible: * =\< 10 pack-year smoking history * p16-positive carcinoma of the oropharynx or unknown primary that are T0-3, N0-1 (AJCC 8th Edition) * Note: in the event that a registered patient with =\< 10 pack-years has a p16-positive result on central review with the tumor and nodal stage T0-3, N0-1 (AJCC 8th Edition), then the site will be notified that the patient is ineligible * Zubrod performance status \>= 3 * Body weight =\< 30 kg * Patients with oral cavity cancer are excluded from participation if the patient is medically operable and resection of the primary tumor is considered technically feasible by an oral or head and neck cancers surgical subspecialist;(please consult the surgical oncology co-principal investigator \[PI\], Steven Chang, Doctor of Medicine \[MD\], if clarification is needed on an individual case) * Sodium \< 130 mmol/L or \> 155 mmol/L (within 14 days of step 1 registration, unless corrected prior to step 1 registration) * Potassium \< 3.5 mmol/L or \> 6 mmol/L (within 14 days of step 1 registration, unless corrected prior to step 1 registration) * Fasting glucose \< 40 mg/dl or \> 400 mg/dl (within 14 days of step 1 registration, unless corrected prior to step 1 registration) * Serum calcium (ionized or adjusted for albumin) \< 7 mg/dl or \> 12.5 mg/dl (within 14 days of step 1 registration, unless corrected prior to step 1 registration) * Magnesium \< 0.9 mg/dl or \> 3 mg/dl (within 14 days of step 1 registration, unless corrected prior to step 1 registration) * Unstable angina and/or congestive heart failure requiring hospitalization within 3 months prior to step 1 registration * Transmural myocardial infarction within 3 months prior to step 1 registration * Respiratory illness requiring hospitalization at the time of step 1 registration * Note: if the respiratory illness is resolved and the patient meets the eligibility status above, then the patient can be considered for the trial * Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to require oxygen therapy within 1 year prior to step 1 registration * History of (non-infectious) pneumonitis that required steroids or current pneumonitis * Clinically apparent jaundice and/or known coagulation defects * Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease \[e.g., colitis or Crohn's disease\], diverticulitis \[with the exception of diverticulosis\], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome \[granulomatosis with polyangiitis\], Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.) * The following are exceptions to this criterion: * Patients with vitiligo or alopecia; * Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on hormone replacement; * Any chronic skin condition that does not require systemic therapy; * Patients without active disease in the last 5 years may be included but only after consultation with the medical oncology study chair; * Patients with celiac disease controlled by diet alone * History of active primary immunodeficiency including, but not limited to acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; Note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; the need to exclude patients with AIDS from this protocol is necessary because the treatment involved in this protocol may be immunosuppressive; patients with known HIV, CD4 counts \>= 200/uL, and undetectable viral loads who are stable on an antiretroviral regimen may be included * Current or prior use of immunosuppressive medication within 14 days before step 1 registration, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid * Receipt of live attenuated vaccination within 30 days prior to step 1 registration * Medical or psychiatric illness which would compromise the patient's ability to tolerate treatment or limit compliance with study requirements * Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception during treatment and for 6 months after the last dose of cetuximab or MEDI14736 (durvalumab); this exclusion is necessary because the treatment involved in this study may be significantly teratogenic; women who are breastfeeding are also excluded * Prior allergic reaction or hypersensitivity to cetuximab or MEDI4736 (durvalumab) or any of study drug excipients * History of allogenic organ transplantation * Uncontrolled hypertension * Uncontrolled cardiac arrhythmia * Uncontrolled serious chronic gastrointestinal condition associated with diarrhea * Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis \[TB\] testing in line with local practice), hepatitis B (known positive hepatitis B virus \[HBV\] surface antigen \[HBsAg\] result), hepatitis C; patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody \[anti-HBc\] and absence of HBsAg) are eligible; patients positive for hepatitis C (hepatitis C virus \[HCV\]) antibody are eligible only if polymerase chain reaction is negative for HCV ribonucleic acid (RNA)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Allegiance Health
Jackson, Michigan, 49201, United States
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Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704, United States
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Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214, United States
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Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401, United States
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Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090, United States
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Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025, United States
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Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina, 28210, United States
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Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina, 28002, United States
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Atrium Health Union/LCI-Union
Monroe, North Carolina, 28112, United States
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Augusta University Medical Center
Augusta, Georgia, 30912, United States
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Aultman Health Foundation
Canton, Ohio, 44710, United States
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Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143, United States
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Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
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Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142, United States
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Aurora Medical Center in Summit
Summit, Wisconsin, 53066, United States
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
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Aurora West Allis Medical Center
West Allis, Wisconsin, 53227, United States
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Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Banner McKee Medical Center
Loveland, Colorado, 80539, United States
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Banner University Medical Center - Tucson
Tucson, Arizona, 85719, United States
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Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
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Beebe Health Campus
Rehoboth Beach, Delaware, 19971, United States
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Beebe South Coastal Health Campus
Millville, Delaware, 19967, United States
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Billings Clinic Cancer Center
Billings, Montana, 59101, United States
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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CTCA at Western Regional Medical Center
Goodyear, Arizona, 85338, United States
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Carle Cancer Center
Urbana, Illinois, 61801, United States
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Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Chelsea Hospital
Chelsea, Michigan, 48118, United States
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Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio, 44906, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708, United States
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Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, 44691, United States
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Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303, United States
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Community Cancer Center East
Indianapolis, Indiana, 46219, United States
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Community Cancer Center North
Indianapolis, Indiana, 46256, United States
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Community Cancer Center South
Indianapolis, Indiana, 46227, United States
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Crossroads Cancer Center
Effingham, Illinois, 62401, United States
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Crozer-Keystone Regional Cancer Center at Broomall
Broomall, Pennsylvania, 19008, United States
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Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756, United States
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Decatur Memorial Hospital
Decatur, Illinois, 62526, United States
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East Jefferson General Hospital
Metairie, Louisiana, 70006, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
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Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
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Forbes Hospital
Monroeville, Pennsylvania, 15146, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Fresno Cancer Center
Fresno, California, 93720, United States
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Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095, United States
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Geauga Hospital
Chardon, Ohio, 44024, United States
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Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
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Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837, United States
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Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711, United States
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Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California, 96161, United States
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Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651, United States
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Good Samaritan Hospital
Corvallis, Oregon, 97330, United States
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Grady Health System
Atlanta, Georgia, 30303, United States
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Greater Baltimore Medical Center
Baltimore, Maryland, 21204, United States
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Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
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Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, 18840, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813, United States
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Helen F Graham Cancer Center
Newark, Delaware, 19713, United States
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Hennepin County Medical Center
Minneapolis, Minnesota, 55415, United States
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Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038, United States
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Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322, United States
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IU Health North Hospital
Carmel, Indiana, 46032, United States
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Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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James J Peters VA Medical Center
The Bronx, New York, 10468, United States
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Jefferson Abington Hospital
Abington, Pennsylvania, 19001, United States
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John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612, United States
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Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080, United States
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Kaiser Permanente Downtown Commons
Sacramento, California, 95814, United States
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Kaiser Permanente Dublin
Dublin, California, 94568, United States
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Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051, United States
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Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688, United States
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Kaiser Permanente Northwest
Portland, Oregon, 97227, United States
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Kaiser Permanente Oakland-Broadway
Oakland, California, 94611, United States
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Kaiser Permanente San Leandro
San Leandro, California, 94577, United States
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Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531, United States
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Kaiser Permanente-Fremont
Fremont, California, 94538, United States
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Kaiser Permanente-Fresno
Fresno, California, 93720, United States
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Kaiser Permanente-Modesto
Modesto, California, 95356, United States
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Kaiser Permanente-Oakland
Oakland, California, 94611, United States
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Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670, United States
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Kaiser Permanente-Richmond
Richmond, California, 94801, United States
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Kaiser Permanente-Roseville
Roseville, California, 95661, United States
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Kaiser Permanente-San Francisco
San Francisco, California, 94115, United States
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Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403, United States
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Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119, United States
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Kaiser Permanente-South Sacramento
Sacramento, California, 95823, United States
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Kaiser Permanente-South San Francisco
South San Francisco, California, 94080, United States
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Kaiser Permanente-Stockton
Stockton, California, 95210, United States
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Kaiser Permanente-Vallejo
Vallejo, California, 94589, United States
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Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596, United States
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Kaiser San Rafael-Gallinas
San Rafael, California, 94903, United States
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Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, 48910, United States
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Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805, United States
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Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016, United States
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Lewistown Hospital
Lewistown, Pennsylvania, 17044, United States
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Logan Health Medical Center
Kalispell, Montana, 59901, United States
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London Regional Cancer Program
London, Ontario, N6A 4L6, Canada
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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McLaren Cancer Institute-Bay City
Bay City, Michigan, 48706, United States
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McLaren Cancer Institute-Clarkston
Clarkston, Michigan, 48346, United States
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McLaren Cancer Institute-Flint
Flint, Michigan, 48532, United States
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McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan, 48446, United States
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McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, 48043, United States
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McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, 49770, United States
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McLaren-Port Huron
Port Huron, Michigan, 48060, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Hospital North
Colorado Springs, Colorado, 80920, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Mercy Cancer Center-West Lakes
Clive, Iowa, 50325, United States
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Mercy Hospital Saint Louis
St Louis, Missouri, 63141, United States
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Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
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Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
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MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
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Mid-Michigan Physicians-Lansing
Lansing, Michigan, 48912, United States
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Miller-Dwan Hospital
Duluth, Minnesota, 55805, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803, United States
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New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico, 87109, United States
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North Coast Cancer Care
Sandusky, Ohio, 44870, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Norton Brownsboro Hospital and Medical Campus
Louisville, Kentucky, 40241, United States
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Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, 40202, United States
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OSF Saint Francis Medical Center
Peoria, Illinois, 61637, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Parkview Hospital Randallia
Fort Wayne, Indiana, 46805, United States
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Parkview Regional Medical Center
Fort Wayne, Indiana, 46845, United States
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Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
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Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907, United States
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Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
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ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066, United States
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ProMedica Flower Hospital
Sylvania, Ohio, 43560, United States
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Providence Saint Vincent Medical Center
Portland, Oregon, 97225, United States
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Queen's Medical Center
Honolulu, Hawaii, 96813, United States
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Reading Hospital
West Reading, Pennsylvania, 19611, United States
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Regions Hospital
Saint Paul, Minnesota, 55101, United States
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Rock Hill Radiation Therapy Center
Rock Hill, South Carolina, 29730, United States
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Rohnert Park Cancer Center
Rohnert Park, California, 94928, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605, United States
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Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687, United States
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Saint Francis Medical Center
Cape Girardeau, Missouri, 63703, United States
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Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301, United States
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Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303, United States
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Salina Regional Health Center
Salina, Kansas, 67401, United States
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Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601, United States
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Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
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Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134, United States
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Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
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Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana, 46202, United States
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Singh and Arora Hematology Oncology PC
Flint, Michigan, 48532, United States
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital-Hamden Care Center
Hamden, Connecticut, 06518, United States
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South Sacramento Cancer Center
Sacramento, California, 95823, United States
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Spartanburg Medical Center
Spartanburg, South Carolina, 29303, United States
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Springfield Memorial Hospital
Springfield, Illinois, 62781, United States
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Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304, United States
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State University of New York Upstate Medical University
Syracuse, New York, 13210, United States
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Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
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Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603, United States
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Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661, United States
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Sutter Medical Center Sacramento
Sacramento, California, 95816, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817, United States
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The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202, United States
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The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678, United States
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The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Quebec, H3H 2R9, Canada
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Torrance Memorial Medical Center
Torrance, California, 90509, United States
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Torrance Memorial Physician Network - Cancer Care
Torrance, California, 90505, United States
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Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114, United States
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Trinity Health Medical Center - Canton
Canton, Michigan, 48188, United States
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UCSF Medical Center-Mission Bay
San Francisco, California, 94158, United States
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UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
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UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060, United States
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UHHS-Westlake Medical Center
Westlake, Ohio, 44145, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, 15232, United States
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UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188, United States
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Unity Hospital
Fridley, Minnesota, 55432, United States
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University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069, United States
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University of Illinois
Chicago, Illinois, 60612, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912, United States
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University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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University of Washington Medical Center - Montlake
Seattle, Washington, 98195, United States
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University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin, 53038, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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VA Palo Alto Health Care System
Palo Alto, California, 94304, United States
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VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
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Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
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West Virginia University Healthcare
Morgantown, West Virginia, 26506, United States
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Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401, United States
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Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, 15090, United States
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Yale University
New Haven, Connecticut, 06520, United States
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Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin, 53295, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New PET tracer aims to light up hidden cancer targets
- Can immunotherapy before surgery stop early oral cancer from returning?
- Can a glowing dye show surgeons where head and neck tumors end?
- Can a Four-Part combo before surgery wipe out head and neck tumors?
- Can a new drug shrink advanced solid tumors?
- Can steroid shots shield salivary glands from radiation damage?