STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Clinical trials for STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 explained in plain language.
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New combo therapy before surgery may boost cancer fight in head and neck patients
Disease control Recruiting nowThis study is for people with head and neck cancer that has come back or not gone away. It tests if adding chemotherapy or a chemo-immunotherapy combination before standard salvage surgery can improve outcomes. About 180 participants will receive either chemo or chemo-immunothera…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 09:30 UTC
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New drug combo aims to boost radiation therapy for head and neck cancer
Disease control Recruiting nowThis early-phase trial tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe for people with advanced head and neck cancer. Ipatasertib may help stop cancer cells from growing. About 46 adults with certain types of head and neck can…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 09:29 UTC
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Can adding chemo to radiation stop head and neck cancer from coming back?
Disease control Recruiting nowThis study compares two treatments for people with stage III-IVA head and neck cancer who have already had surgery to remove their tumor. One group gets radiation therapy alone, and the other gets radiation plus the chemotherapy drug cisplatin. The goal is to see which approach b…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated May 26, 2026 08:35 UTC
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New drug aims to ease painful mouth sores for head and neck cancer patients
Symptom relief Recruiting nowThis study tests if adding BMX-001 to standard care can reduce severe mouth sores caused by chemoradiation in head and neck cancer patients. About 98 adults will receive either BMX-001 or a placebo alongside their usual treatment. The goal is to see if BMX-001 helps prevent painf…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated May 20, 2026 11:55 UTC
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New imaging study aims to spot radiation damage to neck arteries
Knowledge-focused Recruiting nowThis study is for people with head and neck cancers who are getting radiation therapy. It uses special PET/CT scans to see how radiation affects the blood vessels in the neck. The goal is to learn if a newer scan method (F-18 NaF PET/CT) can detect these changes better than the s…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Emory University • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Can a simple exercise prevent swallowing problems? new study investigates why some patients skip it.
Knowledge-focused Recruiting nowThis study looks at why people with head and neck cancer do or do not follow swallowing exercises after radiation. Researchers will use blood tests and questionnaires to see if immune system proteins or feelings about the disease affect exercise habits. The goal is to find ways t…
Matched conditions: STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 22, 2026 13:55 UTC