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Could a simple pill replace the drill for toothache emergencies?

NCT ID NCT02629042

Symptom relief Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potentially making the procedure less painful and more convenient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
prednisolone
What this could lead to
If it works, this could offer a simpler, less painful way to manage severe toothache before a full root canal.
What could go wrong
This was a very small trial (only 5 participants) and results may not apply to everyone. The drug may not control pain as well as the standard procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

5 people

The number who actually took part.

Started

May 2017

Finished

Dec 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical signs of irreversible pulpitis on a mandibular molar, * ASA1 or ASA2 score (American Society of Anesthesiologists) * Age between 18 and 70 years (of either gender) * Ability to give written informed consent * Affiliation to a health insurance scheme * Agreement to be contacted by phone 24h after the emergency visit * Availability to come back 72 hours after the emergency visit for endodontic treatment Exclusion Criteria: * Diagnosis of reversible pulpitis, acute apical periodontitis, periodontal lesion of endodontic origin or dentin syndrome * Not retainable tooth requiring extraction * Contraindication of endodontic treatment (endocarditis risk) or local anaesthesia * Contraindication for the prescription of glucocorticoids, paracetamol or codeine, * Oral infection, viral disease in evolution (hepatitis, herpes zoster, .. ), * Machine operators , * Psychosis uncontrolled by treatment, or chronic consumption of drugs or alcohol * Allergy to one or more of the components, * Diabetes, drug intake with direct interaction with glucocorticoids, paracetamol or codeine, * Woman of child-bearing age without contraceptive, pregnancy, breastfeeding * Not able to give informed consent, * Participating in another interventional study

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Conditions

The condition(s) this trial relates to.

agnosia pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis

Contacts and locations

Locations

  • CHU de Bordeaux

    Bordeaux, 33000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.