New gum graft material could reduce pain for receding gums
NCT ID NCT03162016
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new material called Mucoderm, made from donated animal tissue, to treat receding gums. It compared it to the standard treatment, which uses a small piece of tissue from the patient's own palate. The goal was to see if Mucoderm could cover exposed tooth roots just as well but with less pain. Twelve patients with gum recession on both sides of their mouth received one treatment on each side, and the results were compared after 6 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mucoderm (xenogenic acellular dermal matrix)
- What this could lead to
- If successful, this could offer a less painful alternative to traditional gum grafting for treating receding gums.
- What could go wrong
- This is a very small, early study with only 12 patients, so results may not apply to everyone. The new material may not cover roots as well as the standard graft.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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12 people
The number who actually took part.
- Started
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Jun 2017
- Finished
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Sep 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients \> 45 years, postmenopausal women (ie with amenorrhea for more than a year). * Subject with bilateral Miller class I or II recessions defects * non smoking patients * patients having read and understood the information note on the study and signed the informed consent form. * patients affiliated to the social security system. Exclusion Criteria: * Patient with absolute contra-indication for dental surgery: valvular heart disease at risk of infectious endocarditis, recent myocardal (≤ 12 months), organ transplants, recent placement of a coronary stent (≤ 12 months), transient ischemic attacks recurrent, cardiovascular instability, uncontrolled epilepsy, rheumatic fever. * Patient with metabolic bone disease (Paget's disease, osteomalacia, osteogenesis imperfecta) * Patient with an ASA score ≥ 3. * Patient with absolute contra-indication to dental surgery * Patient with severe hematologic disease * Patient with I or type II diabetes * Patients with previous or current acute illness or severe chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, neuro-psychiatric, considered by the investigator to be incompatible with the conduct of the study. * Patients treated with retinoids, oral bisphosphonates, oral anticoagulants or anticonvulsants. * Patient have or have had cancer of the upper aerodigestive tract treated by radiotherapy. * Patient taking a steroidal or non-steroidal anti-inflammatory, anti-cancer or immunosuppressive chemotherapy in the last 6 months. * Patient monitoring considered difficult by the investigator. * Patient with poor oral hygiene incompatible with oral surgery. * Patients with periodontal disease unstabilized * Patient with oral dermatitis or adverse occlusion. * Patient with an acute or chronic infection of the surgical site (osteomyelitis). * Patient with a known allergy to collagen * Patient with autoimmune disease * Patient with a linguistic or mental incapacity to understand information * Patient younger than 45 years old * Patient trust under curatorship or judicial protection * Patients aged over 45 premenopausal. * Patient participating in another clinical study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU de Nice
Nice, France, 06000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gum graft surgery: does the bed matter for thin gums?
- Boosting gum grafts: do blood or gel Add-Ons reduce shrinkage?
- Can a new flap technique better cover receding gums?
- A new twist on gum surgery could better cover exposed roots
- Gum graft boost: growth factors may strengthen receding gum repair
- Micro-needling vs. gum graft: a tiny trial tests a simpler fix for receding gums