Could a cold rinse and diabetes drug soothe root canal pain?
NCT ID NCT07437612
First seen Jun 25, 2026 · Last updated Sep 17, 2026 · Updated 4 times
Summary
This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain was tracked for a week using a standard scale. The goal is to find better ways to manage post-treatment discomfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- metformin and calcium hydroxide (intracanal medicaments) and cold saline (cryotherapy)
- What this could lead to
- If effective, this approach could offer a simple, low-cost way to reduce pain after root canal treatment.
- What could go wrong
- This is a small, early-phase trial (80 people) testing pain relief, not a cure. Results may not apply to all teeth or patients, and the effect may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Systemically healthy participants. Mandibular premolar teeth diagnosed with pulpal necrosis and symptomatic apical periodontitis and indicated for root canal treatment. Periapical index (PAI) score of 1 or 2. Aged between 18 and 70 years. Able to understand and complete visual analog scale (VAS) assessments. Provided written informed consent. Exclusion Criteria: Any systemic disease or pregnancy. Use of analgesics within 24 hours prior to treatment. Severe bruxism. Presence of acute apical abscess or swelling. Periodontal pocket depth greater than 5 mm or tooth mobility exceeding grade 1. Teeth deemed unrestorable. Presence of vital pulpal tissue or immature apices. Radiographic evidence of root resorption, root fracture, perforation, or canal calcification.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Saglik Bilimleri University
Istanbul, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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